rs79346194

This is a coding sequence variant variant in the DEPTOR gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

glomerular filtration rate

Liu H et al. “Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease.” Nature Genetics 54(7):950-962 (2022)

Allele G

OR 6.39

p 2.0e-10

N 1,508,659

Large GWAS

multi-ancestry

Wuttke M et al. “A catalog of genetic loci associated with kidney function from analyses of a million individuals.” Nature Genetics 51(6):957-972 (2019)

Allele G

OR 0.00

p 2.0e-8

N 765,348

Large GWAS

multi-ancestry

About DEPTOR

Enables phosphatidic acid binding activity and protein serine/threonine kinase inhibitor activity. Involved in several processes, including negative regulation of TOR signaling; negative regulation of cell size; and negative regulation of protein kinase activity. Is active in lysosomal membrane. [provided by Alliance of Genome Resources, Jul 2025]

View all DEPTOR variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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