DEPTOR
DEP domain containing MTOR interacting protein
Summary
Enables phosphatidic acid binding activity and protein serine/threonine kinase inhibitor activity. Involved in several processes, including negative regulation of TOR signaling; negative regulation of cell size; and negative regulation of protein kinase activity. Is active in lysosomal membrane. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants42 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs560535814 | 8:120,886,091 | A/T | — | uncertain significance |
| rs150570739 | 8:120,886,121 | G/A | — | uncertain significance |
| rs1174271165 | 8:120,886,148 | G/A | — | uncertain significance |
| rs1277129570 | 8:120,886,174 | A/G | — | uncertain significance |
| rs79346194 | 8:120,886,486 | A/G | coding sequence variant | — |
| rs73703112 | 8:120,886,544 | T/G | coding sequence variant | — |
| rs10110223 | 8:120,887,566 | G/C | — | — |
| rs4871013 | 8:120,907,990 | C/T | regulatory region variant | — |
| rs13281991 | 8:120,923,574 | T/G | — | — |
| rs57411572 | 8:120,935,819 | T/C | intron variant | — |
| rs10808505 | 8:120,940,206 | T/G | intron variant | — |
| rs764932775 | 8:120,940,680 | C/T | — | uncertain significance |
| rs775505421 | 8:120,940,738 | T/C | — | uncertain significance |
| rs762470571 | 8:120,942,100 | G/A | — | uncertain significance |
| rs753877147 | 8:120,942,148 | C/T | — | uncertain significance |
| rs7005380 | 8:120,953,873 | G/C | — | — |
| rs138302507 | 8:120,965,314 | C/T | intron variant | — |
| rs770738642 | 8:120,977,521 | G/T | — | uncertain significance |
| rs1322053461 | 8:120,977,532 | G/C | — | uncertain significance |
| rs144134193 | 8:120,977,591 | C/A | — | uncertain significance |
| rs1814954 | 8:120,985,248 | T/C | intron variant | — |
| rs7823956 | 8:120,992,183 | A/T | intron variant | — |
| rs149165710 | 8:121,002,676 | G/A | intron variant | — |
| rs2488314009 | 8:121,013,803 | A/G | — | uncertain significance |
| rs2488314117 | 8:121,013,853 | A/G | — | uncertain significance |
| rs144026723 | 8:121,013,854 | A/G | — | likely benign |
| rs373056042 | 8:121,013,926 | G/A | — | uncertain significance |
| rs758282195 | 8:121,015,232 | G/T | — | uncertain significance |
| rs751707000 | 8:121,015,242 | G/T | — | uncertain significance |
| rs573198788 | 8:121,015,246 | C/G | — | uncertain significance |
| rs2488316969 | 8:121,015,290 | T/C | — | uncertain significance |
| rs780259678 | 8:121,015,329 | G/A | — | uncertain significance |
| rs571091566 | 8:121,017,952 | C/T | — | — |
| rs1543201 | 8:121,018,888 | A/C | — | — |
| rs372128084 | 8:121,019,084 | C/T | — | likely benign |
| rs200067665 | 8:121,021,279 | C/T | — | likely benign |
| rs747255387 | 8:121,021,281 | C/T | — | uncertain significance |
| rs147712866 | 8:121,021,305 | G/A | — | conflicting classifications of pathogenicity |
| rs546279612 | 8:121,021,358 | G/A | — | uncertain significance |
| rs11995866 | 8:121,058,098 | G/A | intron variant | — |
| rs1387086577 | 8:121,061,842 | G/A | — | uncertain significance |
| rs145750961 | 8:121,061,848 | A/G | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.