rs7943721

This is a regulatory region variant variant in the FAM168A gene.

▶

GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

smoking initiation

Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)

Allele A

OR 0.01

p 9.0e-29

N 3,382,012

Large GWAS

European, East Asian, Hispanic or Latin American, African unspecified

social inhibition quality, attention deficit hyperactivity disorder, substance abuse

Karlsson Linnér R et al. “Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction.” Nature Neuroscience 24(10):1367-1376 (2021)

Allele G

OR 0.01

p 2.0e-11

N 2,776,348

Large GWAS

European

smoking status measurement

Liu M et al. “Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use.” Nature Genetics 51(2):237-244 (2019)

Allele A

OR 0.02

p 4.0e-10

N 1,232,091

Large GWAS

European

substance-related disorder

Lai D et al. “Genome-wide meta-analyses of cross substance use disorders in diverse populations.” Molecular Psychiatry 31(3):1619-1633 (2026)

Allele A

OR 5.67

p 1.0e-8

N 1,517,369

Large GWAS

multi-ancestry

About FAM168A

Involved in positive regulation of base-excision repair. [provided by Alliance of Genome Resources, Jul 2025]

View all FAM168A variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Sign in to join the discussion.

Loading comments…