rs7953257
This variant is located in the HECTD4 gene.
▶GWAS Catalog Trait Associations (7)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (7)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
diastolic blood pressure, alcohol drinking
Feitosa MF et al. “Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.” Plos One 13(6):e0198166 (2018)
Allele A
OR —
p 5.0e-39
N 133,351
Large GWAS
multi-ancestry
systolic blood pressure, alcohol drinking
Feitosa MF et al. “Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.” Plos One 13(6):e0198166 (2018)
Allele A
OR —
p 4.0e-20
N 133,355
Large GWAS
multi-ancestry
diastolic blood pressure, alcohol consumption quality
Feitosa MF et al. “Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.” Plos One 13(6):e0198166 (2018)
Allele A
OR —
p 8.0e-19
N 72,871
Large GWAS
multi-ancestry
lean body mass
Harris BHL et al. “New role of fat-free mass in cancer risk linked with genetic predisposition.” Scientific Reports 14(1):7270 (2024)
Allele T
OR 0.01
p 1.0e-13
N 337,739
Large GWAS
European
systolic blood pressure
Yang ML et al. “Sex-specific genetic architecture of blood pressure.” Nature Medicine 30(3):818-828 (2024)
Allele A
OR 0.02
p 1.0e-10
N 174,664
Large GWAS
multi-ancestry
mean arterial pressure, alcohol drinking
Feitosa MF et al. “Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.” Plos One 13(6):e0198166 (2018)
Allele A
OR —
p 3.0e-10
N 133,361
Large GWAS
multi-ancestry
diastolic blood pressure
Yang ML et al. “Sex-specific genetic architecture of blood pressure.” Nature Medicine 30(3):818-828 (2024)
Allele A
OR 0.04
p 1.0e-34
N 174,664
Large GWAS
multi-ancestry
About HECTD4
Predicted to enable ubiquitin-protein transferase activity. Involved in glucose homeostasis and glucose metabolic process. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
View all HECTD4 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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