rs79717953
This is a coding sequence variant variant in the CD109 gene.
▶GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
heel bone mineral density
Morris JA et al. “An atlas of genetic influences on osteoporosis in humans and mice.” Nature Genetics 51(2):258-266 (2019)
Allele C
OR 0.08
p 2.0e-17
N 426,824
Large GWAS
European
myocardial infarction
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele T
OR 0.14
p 2.0e-9
N 623,029
Large GWAS
multi-ancestry
coronary artery disease
Tcheandjieu C et al. “Large-scale genome-wide association study of coronary artery disease in genetically diverse populations.” Nature Medicine 28(8):1679-1692 (2022)
Allele T
OR 0.11
p 2.0e-8
N 1,077,578
Large GWAS
multi-ancestry
angina pectoris
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele T
OR 0.14
p 3.0e-8
N 159,165
Large GWAS
East Asian
About CD109
This gene encodes a glycosyl phosphatidylinositol (GPI)-linked glycoprotein that localizes to the surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signalling by transforming growth factor beta (TGF-beta). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
View all CD109 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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