rs8008068

This is a downstream gene variant variant in the SYNE2 gene.

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GWAS Catalog Trait Associations (10)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

level of ceramide

Cadby G et al. “Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease.” Nature Communications 13(1):3124 (2022)
Allele G
OR 0.26
p 3.0e-18
N 4,492
Large GWAS
European
Huang Y et al. “Genetic factors shaping the plasma lipidome and the relations to cardiometabolic risk in children and adolescents.” Ebiomedicine 112:105537 (2025)
Allele G
OR 0.36
p 7.0e-10
N 1,149
Large GWAS
European

serum metabolite level

Feofanova EV et al. “A Genome-wide Association Study Discovers 46 Loci of the Human Metabolome in the Hispanic Community Health Study/Study of Latinos.” American Journal of Human Genetics 107(5):849-863 (2020)
Allele A
OR 0.23
p 5.0e-18
N 3,926
Large GWAS
multi-ancestry

glycosyl ceramide (d16:1/24:1, d18:1/22:1) measurement

Yin X et al. “Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci.” Nature Communications 13(1):1644 (2022)
Allele G
OR 0.37
p 2.0e-17
N 6,136
Large GWAS
European

metabolite measurement

Tahir UA et al. “Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals.” Nature Communications 13(1):4923 (2022)
Allele G
OR 0.23
p 4.0e-15
N 2,466
Large GWAS
multi-ancestry

sphingomyelin measurement

Huang Y et al. “Genetic factors shaping the plasma lipidome and the relations to cardiometabolic risk in children and adolescents.” Ebiomedicine 112:105537 (2025)
Allele G
OR 0.44
p 2.0e-14
N 1,149
Large GWAS
European
Harshfield EL et al. “Genome-wide analysis of blood lipid metabolites in over 5000 South Asians reveals biological insights at cardiometabolic disease loci.” Bmc Medicine 19(1):232 (2021)
Allele G
OR 0.05
p 5.0e-10
N 5,662
Large GWAS
South Asian
Tabassum R et al. “Genetic architecture of human plasma lipidome and its link to cardiovascular disease.” Nature Communications 10(1):4329 (2019)
Allele G
OR 0.31
p 4.0e-11
N 2,045
Large GWAS
European

glycosyl ceramide (d18:1/20:0, d16:1/22:0) measurement

Yin X et al. “Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci.” Nature Communications 13(1):1644 (2022)
Allele G
OR 0.23
p 4.0e-11
N 6,136
Large GWAS
European

Red cell distribution width

Astle WJ et al. “The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.” Cell 167(5):1415-1429.e19 (2016)
Allele G
OR 0.03
p 6.0e-11
N 171,529
Large GWAS
European

About SYNE2

The protein encoded by this gene is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

View all SYNE2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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