rs80245686

This variant is located in the RABGAP1L gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

substance-related disorder

Lai D et al. “Genome-wide meta-analyses of cross substance use disorders in diverse populations.” Molecular Psychiatry 31(3):1619-1633 (2026)

Allele T

OR 5.51

p 3.0e-8

N 1,699,295

Large GWAS

multi-ancestry

About RABGAP1L

Enables GTPase activator activity and small GTPase binding activity. Acts upstream of or within regulation of protein localization. Located in several cellular components, including Golgi apparatus; cilium; and early endosome. [provided by Alliance of Genome Resources, Jul 2025]

View all RABGAP1L variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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