rs8076131
This is a regulatory region variant variant in the ORMDL3 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
asthma
Herrera-Luis E et al. “Genome-wide association study reveals a novel locus for asthma with severe exacerbations in diverse populations.” Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology 32(1):106-115 (2021)
Allele A
OR 1.45
p 3.0e-10
N 3,310
Large GWAS
multi-ancestry
About ORMDL3
Involved in ceramide metabolic process. Acts upstream of or within several processes, including negative regulation of B cell apoptotic process; negative regulation of ceramide biosynthetic process; and positive regulation of protein localization to nucleus. Located in endoplasmic reticulum. Part of serine palmitoyltransferase complex. [provided by Alliance of Genome Resources, Jul 2025]
View all ORMDL3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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