rs8079626

This is a regulatory region variant variant in the BAIAP2 gene.

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Research that mentions this SNP (2)

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The monoamine oxidase B gene exhibits significant association to ADHD
ReviewJun Li et al.(2008)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

This review of molecular genetic studies of ADHD in Han Chinese populations summarizes candidate gene studies across dopaminergic, noradrenergic, serotonergic, and enzymatic systems, along with the first GWAS in Chinese ADHD cases (n=1040) and controls (n=963). While no single gene has been definitively identified, significant associations include DRD4 7-repeat allele (OR=1.70, 95% CI 1.20-2.40, p=0.003 in males), DBH rs2519152, and various polymorphisms in COMT, NET1, and serotonin genes, though results remain inconsistent across studies.

Traits studied:ADHD-Combined subtypeADHD-Hyperactive/Impulsive subtypeADHD-Inattentive subtypeAttentionAttention deficit hyperactivity disorderDisruptive behavior disorder comorbidityExecutive functionIQLearning disorder comorbidityOppositional defiant disorder comorbidityResponse inhibitionTic disorder comorbidityWorking memory
PubMedDOIMetascience Observatory
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Monoamine oxidase A gene polymorphism predicts adolescent outcome of attention‐deficit/hyperactivity disorder
ReviewJun Li et al.(2007)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

This review examines molecular genetic studies of attention-deficit hyperactivity disorder (ADHD) in Han Chinese samples, including candidate gene studies, endophenotype research, genome-wide association studies, and pharmacogenomic investigations. Eight GWAS conducted for ADHD have been inconclusive with no genome-wide significant associations identified, though candidate gene studies have identified associations with dopaminergic (DAT1, DRD4, DRD2, DRD3), noradrenergic (NET1, ADRA2A, ADRA2C), serotonergic (SLC6A4, HTR genes), and metabolic pathway genes (COMT, MAOA, MAOB, DBH, TPH). A meta-analysis of DRD4 longer repeats showed OR=1.70-1.74 in males with ADHD-C subtype.

Traits studied:ADHD combined subtype (ADHD-C)ADHD primarily hyperactive/impulsive subtype (ADHD-HI)ADHD primarily inattentive subtype (ADHD-I)ADHD with comorbid disruptive behavior disorder (DBD)ADHD with comorbid learning disorderADHD with comorbid oppositional defiant disorder (ODD)ADHD with comorbid tic disorderAttention-deficit hyperactivity disorder (ADHD)Executive functionImpulsivityIntelligence quotient (IQ)Response inhibition
PubMedDOIMetascience Observatory

About BAIAP2

The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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