rs823154
This is a regulatory region variant variant in the SLC41A1 gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
Tinnitus
Clifford RE et al. “Genetic architecture distinguishes tinnitus from hearing loss.” Nature Communications 15(1):614 (2024)
Allele T
OR 5.49
p 4.0e-8
N 596,905
Large GWAS
multi-ancestry
neuroimaging measurement
Smith SM et al. “An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank.” Nature Neuroscience 24(5):737-745 (2021)
Allele T
OR 0.07
p 2.0e-13
N 21,282
Major Consortium StudyLarge GWAS
European
About SLC41A1
Enables magnesium:sodium antiporter activity. Involved in cellular response to magnesium ion; intracellular magnesium ion homeostasis; and magnesium ion transmembrane transport. Located in basolateral plasma membrane. Part of protein-containing complex. Implicated in nephronophthisis. [provided by Alliance of Genome Resources, Jul 2025]
View all SLC41A1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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