rs846111

This is a protein-altering variant in the RNF207 gene.

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GWAS Catalog Trait Associations (6)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

JT interval

Young WJ et al. “Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways.” Nature Communications 13(1):5144 (2022)
Allele C
OR 0.10
p 2.0e-202
N 252,730
Large GWAS
European, African unspecified, Hispanic or Latin American, South East Asian, South Asian

QT interval

Young WJ et al. “Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways.” Nature Communications 13(1):5144 (2022)
Allele C
OR 0.10
p 3.0e-186
N 252,730
Large GWAS
European, African unspecified, Hispanic or Latin American, South East Asian, South Asian
Arking DE et al. “Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.” Nature Genetics 46(8):826-36 (2014)
Allele C
OR 1.73
p 7.0e-40
N 71,061
Large GWAS
European
van Duijvenboden S et al. “Genomic and pleiotropic analyses of resting QT interval identifies novel loci and overlap with atrial electrical disorders.” Human Molecular Genetics 30(24):2513-2523 (2021)
Allele C
OR 0.06
p 8.0e-18
N 24,495
Large GWAS
European
Pfeufer A et al. “Common variants at ten loci modulate the QT interval duration in the QTSCD Study.” Nature Genetics 41(4):407-14 (2009)
Allele C
OR 1.49
p 4.0e-16
N 15,842
Large GWAS
European
Newton-Cheh C et al. “Common variants at ten loci influence QT interval duration in the QTGEN Study.” Nature Genetics 41(4):399-406 (2009)
Allele C
OR 1.75
p 1.0e-16
N 13,685
Large GWAS
European

artificial cardiac pacemaker

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.09
p 2.0e-13
N 446,012
Major Consortium StudyLarge GWAS
European

hypertrophic cardiomyopathy

Tadros R et al. “Large-scale genome-wide association analyses identify novel genetic loci and mechanisms in hypertrophic cardiomyopathy.” Nature Genetics 57(3):530-538 (2025)
Allele G
OR 0.22
p 1.0e-10
N 42,802
Large GWAS
European, African unspecified, Hispanic or Latin American, East Asian, South Asian, NR

atrial fibrillation

Yuan S et al. “Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation.” Nature Communications 16(1):6426 (2025)
Allele C
OR 0.03
p 8.0e-14
N 1,840,341
Large GWAS
European

electrocardiography

Verweij N et al. “The Genetic Makeup of the Electrocardiogram.” Cell Systems 11(3):229-238.e5 (2020)
Allele G
OR 0.04
p 2.0e-9
N 63,706
Major Consortium StudyLarge GWAS
European, NR

About RNF207

Enables Hsp70 protein binding activity and transmembrane transporter binding activity. Involved in positive regulation of gene expression. Located in perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

View all RNF207 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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