rs876498

This is a upstream gene variant variant in the UBASH3A gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Graves disease

White SL et al. “Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases.” Nature Genetics 58(2):307-316 (2026)

Allele A

OR 0.09

p 9.0e-18

N 2,460,657

Large GWAS

multi-ancestry

hypothyroidism

Allele A

OR 0.03

p 7.0e-17

N 2,444,128

Large GWAS

multi-ancestry

About UBASH3A

This gene encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Both family members can negatively regulate T-cell signaling. This family member can facilitate growth factor withdrawal-induced apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]

View all UBASH3A variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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