rs877529

This is a intron variant variant in the CBX7 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

multiple myeloma

Chubb D et al. “Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk.” Nature Genetics 45(10):1221-1225 (2013)

Allele A

OR 1.23

p 8.0e-16

N 9,641

Large GWAS

European

Duran-Lozano L et al. “Germline variants at SOHLH2 influence multiple myeloma risk.” Blood Cancer Journal 11(4):76 (2021)

Allele A

OR 1.15

p 1.0e-9

N 350,263

Large GWAS

European

About CBX7

This gene encodes a protein that contains the CHROMO (CHRomatin Organization MOdifier) domain. The encoded protein is a component of the Polycomb repressive complex 1 (PRC1), and is thought to control the lifespan of several normal human cells. [provided by RefSeq, Oct 2016]

View all CBX7 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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