rs900400

This variant is located in the LINC02029 gene.

▶

GWAS Catalog Trait Associations (11)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

birth weight

Horikoshi M et al. “New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.” Nature Genetics 45(1):76-82 (2013)
Allele C
OR 0.07
p 4.0e-38
N 26,836
Large GWAS
European
Freathy RM et al. “Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight.” Nature Genetics 42(5):430-5 (2010)
Allele C
OR 0.09
p 2.0e-35
N 10,623
Large GWAS
multi-ancestry

triglyceride measurement

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.03
p 1.0e-24
N 391,626
Major Consortium StudyLarge GWAS
European

BMI-adjusted waist-hip ratio

Christakoudi S et al. “GWAS of allometric body-shape indices in UK Biobank identifies loci suggesting associations with morphogenesis, organogenesis, adrenal cell renewal and cancer.” Scientific Reports 11(1):10688 (2021)
Allele C
OR 0.02
p 7.0e-15
N 186,825
Major Consortium StudyLarge GWAS
European

serum alanine aminotransferase amount

Chen VL et al. “Genome-wide association study of serum liver enzymes implicates diverse metabolic and liver pathology.” Nature Communications 12(1):816 (2021)
Allele C
OR 7.20
p 6.0e-13
N 390,812
Large GWAS
multi-ancestry

body mass index

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.02
p 4.0e-12
N 424,217
Major Consortium StudyLarge GWAS
European

calcium measurement

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.03
p 4.0e-12
N 250,919
Major Consortium StudyLarge GWAS
European

age at menarche

Perry JR et al. “Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.” Nature 514(7520):92-97 (2014)
Allele T
OR 0.03
p 2.0e-11
N 182,413
Large GWAS
European

monocyte count

Chen MH et al. “Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.” Cell 182(5):1198-1213.e14 (2020)
Allele C
OR 0.01
p 2.0e-11
N 521,594
Large GWAS
European
▶

Research that mentions this SNP (1)

▶
Genome‐wide association analysis of eating disorder‐related symptoms, behaviors, and personality traits
AssociationN=2,784Vesna Boraska et al.(2012)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

Genome-wide association study of six eating disorder-related phenotypes (Drive for Thinness, Body Dissatisfaction, Bulimia, Weight Fluctuation, Breakfast Skipping, and Childhood Obsessive-Compulsive traits) across 2,698-2,967 individuals from TwinsUK discovery and two independent European replication cohorts. Meta-analysis identified eight genetic variants with suggestive evidence of association (P < 10^-5), including rs7624327 near CCNL1 (P=3.34E-06, OR=1.13 for Bulimia), rs1898111 in SEMA6D (P=7.66E-06, OR=0.872 for OCPD), and rs6894268 in RUFY1 (P=2.38E-06 for Body Dissatisfaction), but no signals reached genome-wide significance threshold (P < 5×10^-8).

Traits studied:Body DissatisfactionBreakfast SkippingBulimiaChildhood Obsessive-Compulsive Personality Disorder traitDrive for ThinnessWeight Fluctuation
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Sign in to join the discussion.

Loading comments…