rs904092

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

IGF-1 measurement

Sinnott-Armstrong N et al. “Genetics of 35 blood and urine biomarkers in the UK Biobank.” Nature Genetics 53(2):185-194 (2021)
Allele G
OR 0.02
p 4.0e-10
N 353,824
Major Consortium StudyLarge GWAS
multi-ancestry

alcohol dependence

Gelernter J et al. “Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.” Molecular Psychiatry 19(1):41-9 (2014)
Allele G
OR 1.30
p 5.0e-9
N 8,884
Large GWAS
multi-ancestry
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Research that mentions this SNP (1)

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ADH1A variation predisposes to personality traits and substance dependence
AssociationN=1,523Lingjun Zuo et al.(2010)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

ADH1A genetic variation predisposes to personality traits and substance dependence across multiple population groups. Agreeableness and Conscientiousness were associated with ADH1A diplotypes, haplotypes, and genotypes in European-American and African-American subjects (p range: 1.7×10⁻⁴ to 0.055), with effects modified by sex and age. Substance dependence was significantly associated with ADH1A variants (p range: 0.008 to 0.060), suggesting ADH1A's role in both personality phenotyping and addiction vulnerability.

Traits studied:Alcohol DependenceAnxiety traitsCocaine DependenceOpioid DependencePersonality - AgreeablenessPersonality - ConscientiousnessPersonality - ExtraversionPersonality - NeuroticismPersonality - Openness to ExperienceSubstance Dependence
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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