rs909525

neutralMag 2.5

This is a intron variant variant in the MAOA gene.

Key Literature Trait Associations

MAOA Activity Level

rs909525 is an intronic tag SNP in strong linkage disequilibrium with the MAOA upstream variable number tandem repeat (uVNTR), a functional promoter polymorphism that modulates expression of monoamine oxidase A, an enzyme that catabolizes serotonin, dopamine, and norepinephrine. The C allele tags the 3-repeat (3R) low-expression uVNTR allele, which produces less MAOA enzyme and slower monoamine degradation. Sabol et al. (1998) demonstrated that 3R and 5R uVNTR alleles drive 2- to 10-fold lower transcription than the 3.5R and 4R high-expression alleles.

Niki Antypa et al. “MAOA and MAOB polymorphisms and anger-related traits in suicidal participants and controls” European Archives of Psychiatry and Clinical Neuroscience (2013)

Allele C

OR —

p 7.0e-3

N 578

Preliminary work

European

Sabol SZ et al. “A functional polymorphism in the monoamine oxidase A gene promoter.” Human Genetics 103(3):273-279 (1998)

Allele C

OR —

p —

Candidate gene study

Čugura T et al. “Differences in SNP genotype distributions between complex and simple suicides.” International Journal of Legal Medicine (2018)

Allele C

OR —

p —

N 772

Preliminary work

European

Balestri M et al. “Maoa and Maob polymorphisms and personality traits in suicide attempters and healthy controls: a preliminary study.” Psychiatry Research (2017)

Allele C

OR —

p —

N 394

Candidate gene study

European

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Research that mentions this SNP (2)

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MAOA and MAOB polymorphisms and anger-related traits in suicidal participants and controls

AssociationN=578Niki Antypa et al.(2013)· European Archives of Psychiatry and Clinical Neuroscience

This case-control study examined associations between MAOA and MAOB SNPs (rs909525, rs6323, rs2064070, rs1799836) and anger-related traits in 261 suicidal participants (171 attempters, 90 completers) and 317 healthy controls. Three MAOA variants showed significant associations with outward anger expression in males (p<0.001), with the rs909525 A allele associated with suicidality (p<0.007). The rs6323 C allele showed association with anger-out in females (p=0.002).

Traits studied:AggressionAnger-related traitsOutward anger expressionSuicidal behaviorSuicide attempt

PubMed DOI Metascience Observatory

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Aggressive behavior, related conduct problems, and variation in genes affecting dopamine turnover

AssociationN=421Elena L. Grigorenko et al.(2010)· Aggressive Behavior

This study investigated 12 genetic polymorphisms in four dopamine-related genes (COMT, MAOA, MAOB, and DBH) in 179 incarcerated male Russian adolescents and 242 matched controls to identify genetic associations with aggressive behavior and conduct disorder. The authors found that while individual genetic variants did not differentiate groups, specific combinations of variants (haplotypes) and interactions between variants within and across genes produced informative classifications for incarceration status (P < 0.0001, Nagelkerke R² = 0.141) and conduct disorder diagnosis (P < 0.0001, Nagelkerke R² = 0.158), with a 4-marker model involving COMT rs737865, COMT rs165599, DBH rs1611115, and DBH rs739398 being most predictive.

Traits studied:Aggressive behaviorConduct disorderIncarceration statusViolent criminal behavior

rs909525

Key Literature Trait Associations

MAOA Activity Level

Research that mentions this SNP (2)

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