rs909674

This variant is located in the MGAT3 gene.

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GWAS Catalog Trait Associations (8)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

IgG fucosylation measurement

Shen X et al. “Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation.” Nature Communications 8(1):447 (2017)
Allele A
OR —
p 1.0e-20
N 1,960
Large GWAS
European

IgG galactosylation measurement

Shen X et al. “Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation.” Nature Communications 8(1):447 (2017)
Allele A
OR —
p 2.0e-14
N 1,960
Large GWAS
European

IgG disialylation measurement

Shen X et al. “Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation.” Nature Communications 8(1):447 (2017)
Allele A
OR —
p 4.0e-14
N 1,960
Large GWAS
European

IgG sialylation measurement

Shen X et al. “Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation.” Nature Communications 8(1):447 (2017)
Allele A
OR —
p 1.0e-13
N 1,960
Large GWAS
European

IgG digalactosylation measurement

Shen X et al. “Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation.” Nature Communications 8(1):447 (2017)
Allele A
OR —
p 3.0e-13
N 1,960
Large GWAS
European

intelligence

Davies G et al. “Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.” Nature Communications 9(1):2098 (2018)
Allele A
OR 5.62
p 2.0e-8
N 300,486
Large GWAS
European

serum IgG glycosylation measurement

Lauc G et al. “Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.” Plos Genetics 9(1):e1003225 (2013)
Allele C
OR 0.21
p 6.0e-10
N 2,247
Large GWAS
European
Shen X et al. “Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation.” Nature Communications 8(1):447 (2017)
Allele C
OR —
p 3.0e-19
N 1,960
Large GWAS
European

About MGAT3

There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. The enzyme encoded by this gene transfers a GlcNAc residue to the beta-linked mannose of the trimannosyl core of N-linked oligosaccharides and produces a bisecting GlcNAc. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

View all MGAT3 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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