rs915057

This is a intron variant variant in the SYNE2 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

major depressive disorder

Wray NR et al. “Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.” Nature Genetics 50(5):668-681 (2018)

Allele G

OR 1.03

p 8.0e-10

N 480,359

Large GWAS

European

bipolar disorder, major depressive disorder

Coleman JRI et al. “The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls.” Biological Psychiatry 88(2):169-184 (2020)

Allele G

OR 1.02

p 2.0e-8

N 625,026

Large GWAS

European

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ClinVar annotation

Benign★★★☆

2 submitters1 publication

View on ClinVar →

About SYNE2

The protein encoded by this gene is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]