rs9282861

This is a protein-altering variant in the SULT1A1 gene.

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Research that mentions this SNP (2)

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Association of 12 polymorphic variants conferring genetic risk to lung cancer in Indian population: An extensive meta‐analysis
Meta-analysisN=19,556Debmalya Sengupta et al.(2017)· Environmental and Molecular Mutagenesis

A comprehensive meta-analysis of 50 case-control studies from the Indian subcontinent identified genetic variants modifying lung cancer risk, finding FDR-corrected associations for rs3547/XRCC1 (OR=1.83-2.72) and rs1048943/CYP1A1 (OR=2.07). The rs1048943/CYP1A1 variant showed strongest associations with adenocarcinoma (OR=3.38) and squamous cell carcinoma (OR=3.53) with significant effect modification by smoking status. Global meta-analysis confirmed rs1048943/CYP1A1 association across world populations (OR=1.22, p=0.01).

Traits studied:Lung adenocarcinomaLung cancerSmall cell lung carcinomaSquamous cell carcinoma
PubMedDOIMetascience Observatory
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Genome-wide detection of allelic genetic variation to predict biochemical recurrence after radical prostatectomy among prostate cancer patients using an exome SNP chip
AssociationN=776Jong Jin Oh et al.(2015)· Journal of Cancer Research and Clinical Oncology

This exome array study of 776 Korean prostate cancer patients identified eight SNPs (rs77080351 OR 7.23, rs200944490 OR 5.24, rs2071292 OR 3.37, rs117237810 OR 4.86, rs191118242 OR 5.10, rs4965121 OR 2.44, rs61742396 OR 3.24, and rs6573513 OR 1.72) significantly associated with biochemical recurrence after radical prostatectomy. Adding genetic information to clinicopathological models increased predictive accuracy from 85.1% to 89.0% (P=0.025).

Traits studied:AlcoholismBreast cancerColorectal cancerGastric cancerLeukemiaLung cancerMelanomaNephroblastomaNeuroticismPancreatic carcinogenesisPanic disorderProstate cancer biochemical recurrenceRetinoblastomaSchizophrenia
PubMedDOIMetascience Observatory

About SULT1A1

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Multiple alternatively spliced variants that encode two isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

View all SULT1A1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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