SULT1A1
sulfotransferase family 1A member 1
Pharmacogene
Summary
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Multiple alternatively spliced variants that encode two isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Known Variants42 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs9282861 | 16:28,606,193 | C/T | missense variant | — |
| rs1042157 | 16:28,617,057 | G/C | — | — |
| rs6839 | 16:28,617,128 | T/C | 3 prime UTR variant | — |
| rs745498975 | 16:28,617,156 | G/A | — | uncertain significance |
| rs746968899 | 16:28,617,176 | G/A | — | uncertain significance |
| rs569953298 | 16:28,617,188 | G/A | — | uncertain significance |
| rs759725938 | 16:28,617,189 | C/T | — | uncertain significance |
| rs1273827359 | 16:28,617,215 | T/C | — | uncertain significance |
| rs1478709365 | 16:28,617,230 | G/A | — | uncertain significance |
| rs9282864 | 16:28,617,308 | A/G | intron variant | — |
| rs28374453 | 16:28,617,413 | A/C | missense variant | — |
| rs140288278 | 16:28,617,437 | T/G | — | uncertain significance |
| rs765089293 | 16:28,617,458 | T/A | — | uncertain significance |
| rs1801030 | 16:28,617,485 | C/G | missense variant | — |
| rs199630120 | 16:28,617,494 | C/T | — | uncertain significance |
| rs1232887612 | 16:28,617,515 | G/A | — | uncertain significance |
| rs1386951505 | 16:28,617,547 | C/A | — | uncertain significance |
| rs4149392 | 16:28,617,813 | A/G | intron variant | — |
| rs777965756 | 16:28,618,135 | C/G | — | uncertain significance |
| rs771427204 | 16:28,618,150 | C/T | — | uncertain significance |
| rs759716692 | 16:28,618,170 | T/A | — | uncertain significance |
| rs747252974 | 16:28,618,382 | C/T | — | uncertain significance |
| rs1318882961 | 16:28,618,391 | T/C | — | uncertain significance |
| rs777884064 | 16:28,619,652 | A/C | — | uncertain significance |
| rs1041986 | 16:28,619,684 | C/T | — | likely benign |
| rs141343888 | 16:28,619,859 | G/A | — | uncertain significance |
| rs1126446 | 16:28,619,920 | A/G | synonymous variant | — |
| rs752498609 | 16:28,620,053 | G/C | — | uncertain significance |
| rs200542791 | 16:28,620,121 | G/T | — | uncertain significance |
| rs773654777 | 16:28,620,134 | C/T | — | uncertain significance |
| rs138941775 | 16:28,620,150 | G/A | — | likely benign |
| rs372451952 | 16:28,620,151 | C/T | — | uncertain significance |
| rs41278152 | 16:28,620,242 | A/G | regulatory region variant | — |
| rs4149383 | 16:28,620,320 | G/A | regulatory region variant | — |
| rs750155 | 16:28,620,572 | C/T | regulatory region variant | — |
| rs35827316 | 16:28,620,759 | G/T | — | benign |
| rs3760091 | 16:28,620,800 | C/T | — | — |
| rs116852869 | 16:28,622,480 | T/C | intron variant | — |
| rs2925635 | 16:28,622,993 | A/G | — | — |
| rs1462310634 | 16:28,631,385 | A/G | — | uncertain significance |
| rs1968752 | 16:28,631,585 | T/G | intron variant | — |
| rs753526361 | 16:28,634,466 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.