rs9303521

This variant is located in the LINC02210-CRHR1 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

neuroticism measurement

Nagel M et al. “Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.” Nature Genetics 50(7):920-927 (2018)
Allele T
OR 6.44
p 1.0e-10
N 449,484
Meta-analysisLarge GWAS
European
Hill WD et al. “Genetic contributions to two special factors of neuroticism are associated with affluence, higher intelligence, better health, and longer life.” Molecular Psychiatry 25(11):3034-3052 (2020)
Allele T
OR 0.01
p 3.0e-8
N 270,059
Large GWAS
European

bone tissue density

Rivadeneira F et al. “Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.” Nature Genetics 41(11):1199-206 (2009)
Allele T
OR 0.07
p 1.0e-8
N 19,195
Meta-analysisLarge GWAS
European
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Research that mentions this SNP (1)

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Insight in glioma susceptibility through an analysis of 6p22.3, 12p13.33-12.1, 17q22-23.2 and 18q23 SNP genotypes in familial and non-familial glioma
AssociationN=2,175Yanhong Liu et al.(2012)· Human Genetics

This family-based association study identified genetic variants associated with familial glioma by analyzing 5,122 SNPs in four chromosomal regions in 88 glioma cases with family history versus 1,100 without (discovery study) and validated findings in 84 familial and 903 sporadic cases. The strongest associations in the combined analysis were at 12p13.33-12.1 (PRMT8 rs17780102 OR=2.13, SOX5 rs7305773 OR=3.53, STYK1 rs2418087 OR=1.88) and 17q12-21.32 (SPOP rs6504618 OR=2.01, p=0.0006), with significant dose-effect relationship across four risk variants.

Traits studied:Familial gliomaGliomaGlioma with family history of primary brain tumor
PubMedDOIMetascience Observatory

About LINC02210-CRHR1

This locus represents naturally occurring readthrough transcription between neighboring genes CRHR1-IT1, CRHR1 intronic transcript 1 (Gene ID: 147081) and CRHR1, corticotropin releasing hormone receptor 1 (Gene ID: 1394) on chromosome 17. The readthrough transcript encodes a protein that shares sequence identity with the product of the CRHR1 gene. [provided by RefSeq, Dec 2016]

View all LINC02210-CRHR1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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