rs957345

This is a splice region variant variant in the YLPM1 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

total cholesterol measurement

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele G

OR 0.01

p 1.0e-11

N 480,086

Large GWAS

multi-ancestry

gastroesophageal reflux disease

Ong JS et al. “Multitrait genetic association analysis identifies 50 new risk loci for gastro-oesophageal reflux, seven new loci for Barrett's oesophagus and provides insights into clinical heterogeneity in reflux diagnosis.” Gut 71(6):1053-1061 (2022)

Allele C

OR —

β 0.029

p 2.0e-9

N 602,604

Large GWAS

European

About YLPM1

Enables RNA binding activity. Predicted to be involved in regulation of telomere maintenance. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Located in nuclear speck. [provided by Alliance of Genome Resources, Jul 2025]

View all YLPM1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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