rs9611519
This is a synonymous variant in the L3MBTL2 gene — it does not change the protein's amino acid sequence.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
neuroticism measurement
Nagel M et al. “Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.” Nature Genetics 50(7):920-927 (2018)
Allele T
OR 8.84
p 1.0e-18
N 449,484
Meta-analysisLarge GWAS
European
Luciano M et al. “Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism.” Nature Genetics 50(1):6-11 (2018)
Allele T
OR 0.04
p 1.0e-10
N 329,821
Large GWAS
European
Lo MT et al. “Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders.” Nature Genetics 49(1):152-156 (2017)
Allele T
OR 0.05
p 9.0e-9
N 122,867
Large GWAS
European
About L3MBTL2
Enables methylated histone binding activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including ectoderm development; stem cell differentiation; and stem cell proliferation. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2025]
View all L3MBTL2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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