rs9976767

This is a downstream gene variant variant in the UBASH3A gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

type 1 diabetes mellitus

Grant SF et al. “Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes.” Diabetes 58(1):290-5 (2009)

Allele C

OR 1.16

p 2.0e-8

N 2,192

Large GWAS

European

About UBASH3A

This gene encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Both family members can negatively regulate T-cell signaling. This family member can facilitate growth factor withdrawal-induced apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]

View all UBASH3A variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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