Trait
SNPs associated with Warfarin Sensitivity
8 genetic variants across 2 genes have been associated with Warfarin Sensitivity in published research. Key genes include CYP2C9, VKORC1.
Associated variants8 total
| rsid | Gene | Effect | Evidence |
|---|---|---|---|
| rs1799853 | CYP2C9 | Increased warfarin sensitivity | Meta-analysis |
| rs9923231 | VKORC1 | Increased warfarin sensitivity | Meta-analysis |
| rs72558189 | CYP2C9 | Severely reduced CYP2C9 activity; lower warfarin dose needed | Meta-analysis |
| rs1057910 | CYP2C9 | CYP2C9*3 — substantially reduced warfarin metabolism | Major Consortium Study |
| rs9332131 | CYP2C9 | CYP2C9*6 no-function frameshift allele | Major Consortium Study |
| rs28371685 | CYP2C9 | CYP2C9*5 decreased-function warfarin allele | Major Consortium Study |
| rs7900194 | CYP2C9 | — | Large GWAS |
| rs28371686 | CYP2C9 | Reduced warfarin metabolism in African-ancestry populations | Large GWAS |
Associations aggregated from the GWAS Catalog and curated literature. Informational only — not medical advice.