Gene Wizard
genewizard.net
Promethease
by MyHeritage
Gene Wizard vs Promethease: which raw DNA analysis tool in 2026?
Published August 9, 2026 · Updated August 10, 2026
For a decade, Promethease was the default answer to “what do I do with my 23andMe raw data?” It matches your file against SNPedia, the community wiki of SNP research, and returns a report of every matching entry — tens of thousands of them. MyHeritage acquired both Promethease and SNPedia in 2019 [3]; since then SNPedia has seen little updating, and as of 2025 Promethease generates a one-time report, emails it to you, and immediately deletes both your file and the report from its servers [2].
Gene Wizard was built in that gap: a continuously updated knowledge base with literature extraction from new studies, plus the analyses a single-SNP wiki can't do — ancestry-aware polygenic risk scores, pharmacogenomic star alleles, and ClinVar reporting — in an interactive dashboard you can revisit.
The honest summary: Promethease still has the larger single-SNP corpus and the longer track record. Gene Wizard has the fresher science, the modern analyses, and a report you don't have to re-buy. The table below goes row by row.
| Compared | Gene Wizard | Promethease |
|---|---|---|
| Price | $19.99 one-time — full report plus 10 uploads that never expire; free results preview | $25 per report, +$4 for each additional DNA file [1] |
| Knowledge base | Curated associations with ongoing literature extraction from newly published studies | SNPedia wiki — a large corpus, but largely unchanged since the 2019 MyHeritage acquisition [3] |
| Report format | Interactive dashboard you can revisit, filter, and explore; downloadable PDF reports | Static one-time report, emailed as an attachment [2] |
| Polygenic risk scores | Yes — normalized against ancestry-matched reference panels, with confidence intervals | Not offered; reports are single-SNP entries |
| Pharmacogenomics | Detailed educational information on 76 pharmacogenes. Not for healthcare or medical decision making. | Individual drug-related SNP entries only; no star-allele diplotypes |
| ClinVar annotations | Direct matches against ClinVar classifications, with review status shown | Only where individual SNPedia pages happen to cite ClinVar |
| Whole-genome (WGS) support | Yes — VCF, alongside 23andMe and AncestryDNA files | Yes — accepts files from many providers, including VCF |
| Single-SNP breadth | ≈68,000 curated, sourced public variant pages | SNPedia's 100,000+ entries — still the larger single-SNP corpus |
| Data handling | Raw file parsed in memory, never stored; results auto-delete after 7 days and can be deleted anytime | DNA file and report “immediately and permanently deleted” after the report is emailed [2] |
| Updates as science advances | Re-run your file anytime using remaining upload credits against the current knowledge base | Each new snapshot requires purchasing another report |
Which should you use?
Choose Promethease if…
- You want the single largest raw dump of per-SNP literature entries and are comfortable digging through a dense static report yourself.
- You value its decade-plus operating history over newer analyses.
- You only ever want a one-time snapshot and don't plan to revisit results.
Choose Gene Wizard if…
- You want research that reflects studies published after 2019, with each claim linked to its sources.
- You want polygenic risk scores, pharmacogenomic info, ClinVar matching, and ancestry — not only per-SNP lookups.
- You want to preview results free, keep an interactive dashboard, and re-run your file as the science moves.
Try Gene Wizard on your own file
Free preview of your results; one-time $19.99 for the full report — no subscription. Your raw file is never stored.
Also worth reading: Gene Wizard vs Genetic Genie and our roundup of Promethease alternatives in 2026.
Sources
- Promethease pricing: “Most reports cost $25”, additional DNA files $4 each. promethease.com (retrieved August 10, 2026).
- Promethease privacy policy: “Once your Report is generated and emailed to you as an attachment, your DNA Data File and the generated Report are immediately and permanently deleted from our servers.” promethease.com/privacy (retrieved August 10, 2026).
- MyHeritage's 2019 acquisition of Promethease and SNPedia: MyHeritage announcement. SNPedia edit activity since then is minimal and its content largely reflects pre-2019 literature.