Promethease alternatives in 2026: where to analyze raw DNA now

For a decade, the standard advice for anyone with a 23andMe file was "run it through Promethease." That advice has aged badly.

What happened to Promethease and SNPedia

MyHeritage acquired both Promethease and SNPedia in 2019. Since then:

• SNPedia stopped being meaningfully updated. The wiki that powers Promethease reports is largely frozen at 2019-era research. Genetics has not stood still — thousands of new association studies have been published since.
• Promethease became a one-shot report. As of April 2025, Promethease deletes uploaded DNA files and generated reports from its servers immediately after emailing them, and previously stored files were permanently deleted. You get a static HTML report and nothing else.
• The report format itself — thousands of unranked SNPedia excerpts — was always hard to interpret, and there is no ongoing development to fix it.

The result: Promethease still runs, but it's a snapshot of 2019 genetics with a 1990s reading experience.

What to look for in a replacement

• A maintained knowledge base — is new literature actually being added?
• Evidence transparency — does each claim link to the study behind it, with effect sizes and study types visible?
• Polygenic risk scores — modern risk estimation is polygenic; single-SNP reports miss most of the signal.
• Ancestry handling — scores calibrated only on European-ancestry cohorts mislead everyone else unless normalized.
• Data handling — is your raw file stored, and can you delete everything?
• WGS support — if you have whole-genome data, chip-only tools waste it.

The current options

Gene Wizard (free preview, $19.99 one-time)

Gene Wizard was built as a modern Promethease replacement: a continuously updated knowledge base with literature extraction from recent studies, ancestry-aware polygenic risk scores, pharmacogenomic star-allele calling across 76 genes (including CYP2C19 and CYP2D6), ClinVar matches, and public, sourced pages for every notable SNP — for example rs1801133 in MTHFR or rs429358 in APOE. Previewing results is free; a one-time $19.99 — in the same range as Promethease's $15, with no subscription — unlocks the full report and includes 10 uploads that never expire. Raw files are parsed in memory and never stored; results auto-delete after 7 days. Accepts 23andMe, AncestryDNA, and WGS VCFs.

Genetic Genie (free)

A long-running free tool focused on methylation and detox panels, plus GenVue Discovery for browsing health-related variants in your file. Good for a quick look; reports are variant lists without polygenic scores, and interpretation is left to you.

Codegen.eu (free)

Community-run analysis with a large report. Like Promethease, it leans on SNPedia content, so it inherits the staleness problem.

Genomelink (freemium)

Polished trait reports with a free tier and paid subscriptions. Consumer-friendly presentation; less evidence detail per claim than research-oriented tools.

SelfDecode (paid subscription)

Health-optimization platform with polygenic scores and lifestyle recommendations. Substantial content behind a subscription; recommendations go further beyond the primary literature than the tools above.

Sequencing.com (marketplace)

An app marketplace on top of your uploaded genome — many small paid reports of varying quality rather than one coherent analysis.

Bottom line

If you want the old Promethease workflow — upload a raw file, get a comprehensive research-backed report — the closest modern equivalent is a tool with a maintained literature pipeline and polygenic scoring. That's the niche Gene Wizard was built for; the preview is free, the full report is a one-time $19.99, and you can inspect demo results before uploading anything. Whatever you choose, check the data-handling policy first — your raw genome is not a file to hand out casually.

For deeper, referenced write-ups of individual services, see our service reviews.