APCDD1

APC down-regulated 1

Summary

This locus encodes an inhibitor of the Wnt signaling pathway. Mutations at this locus have been associated with hereditary hypotrichosis simplex. Increased expression of this gene may also be associated with colorectal carcinogenesis.[provided by RefSeq, Sep 2010]

Known Variants102 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs77168889	18:10,454,279	C/A	—	benign
rs28769876	18:10,454,960	C/G	—	benign
rs750625563	18:10,454,988	C/T	—	uncertain significance
rs752598200	18:10,455,000	C/G	—	uncertain significance
rs267606659	18:10,455,004	T/G	missense variant	pathogenic
rs28379930	18:10,455,077	A/G	—	benign
rs28484275	18:10,455,133	T/C	—	benign
rs3748418	18:10,468,315	G/A	—	benign
rs3748417	18:10,468,327	A/G	—	benign
rs539412	18:10,468,453	T/C	—	benign
rs768987522	18:10,468,486	C/T	—	uncertain significance
rs35079028	18:10,468,596	A/C	—	benign
rs754697340	18:10,468,602	C/G	—	uncertain significance
rs114256170	18:10,468,635	C/T	—	likely benign
rs2030776317	18:10,468,649	G/A	—	uncertain significance
rs7226906	18:10,471,284	A/C	—	benign
rs78536172	18:10,471,521	G/A	—	benign
rs2510157219	18:10,471,522	C/T	—	likely benign
rs1302943042	18:10,471,625	G/A	—	uncertain significance
rs377223916	18:10,471,669	C/T	—	uncertain significance
rs370464025	18:10,471,676	G/A	—	uncertain significance
rs762580615	18:10,471,706	C/T	—	uncertain significance
rs3748415	18:10,471,732	A/G	—	benign
rs3748414	18:10,471,764	C/T	—	benign
rs116328641	18:10,471,765	G/A	—	uncertain significance
rs3748413	18:10,471,773	C/G	—	benign
rs1392754194	18:10,471,783	G/A	—	uncertain significance
rs200405895	18:10,471,789	C/T	—	uncertain significance
rs550080767	18:10,471,790	G/A	—	uncertain significance
rs370392635	18:10,471,794	A/G	—	likely benign
rs143954637	18:10,471,799	C/T	—	uncertain significance
rs115383241	18:10,471,810	G/A	—	uncertain significance
rs149506112	18:10,471,815	C/T	—	likely benign
rs368134493	18:10,471,816	G/A	—	uncertain significance
rs199591627	18:10,471,858	G/C	—	uncertain significance
rs149668434	18:10,471,867	G/A	—	uncertain significance
rs2030869479	18:10,471,958	A/C	—	uncertain significance
rs1191340876	18:10,471,972	C/G	—	uncertain significance
rs762091049	18:10,471,993	A/G	—	uncertain significance
rs1036419184	18:10,472,002	A/G	—	uncertain significance
rs1057289531	18:10,472,023	C/T	—	uncertain significance
rs770761989	18:10,472,034	C/T	—	benign
rs549800578	18:10,472,038	C/G	—	uncertain significance
rs117942846	18:10,472,074	G/A	—	benign
rs522393	18:10,479,056	G/C	intron variant	—
rs1786682	18:10,481,941	G/A	intron variant	—
rs1662153	18:10,485,044	G/C	intron variant	—
rs518978	18:10,485,250	A/G	—	benign
rs489837	18:10,485,357	T/C	—	benign
rs91958	18:10,485,363	T/C	—	benign
rs91959	18:10,485,369	G/A	—	benign
rs146444390	18:10,485,477	A/G	—	uncertain significance
rs755440394	18:10,485,486	C/G	—	uncertain significance
rs547035524	18:10,485,496	A/G	—	uncertain significance
rs374914282	18:10,485,499	G/A	—	uncertain significance
rs61741632	18:10,485,503	A/G	—	benign
rs143107759	18:10,485,547	C/T	—	uncertain significance
rs114821361	18:10,485,549	A/G	—	likely benign
rs150205350	18:10,485,561	G/A	—	uncertain significance
rs746141096	18:10,485,591	C/T	—	uncertain significance
rs771909445	18:10,485,597	G/A	—	uncertain significance
rs200699860	18:10,485,625	T/C	—	uncertain significance
rs186987345	18:10,485,710	C/T	—	likely benign
rs201920747	18:10,485,711	G/A	—	uncertain significance
rs143146906	18:10,485,714	C/T	—	uncertain significance
rs147066092	18:10,485,721	G/A	—	uncertain significance
rs200939423	18:10,485,730	G/A	—	benign
rs61744718	18:10,485,734	C/T	—	benign
rs116815061	18:10,485,735	G/A	—	benign
rs372013882	18:10,485,742	C/T	—	likely benign
rs9949016	18:10,485,856	G/A	—	benign
rs580258	18:10,487,353	A/G	—	benign
rs538795	18:10,487,443	T/C	—	benign
rs2143567669	18:10,487,593	A/T	—	uncertain significance
rs148807402	18:10,487,617	C/T	—	uncertain significance
rs2031276689	18:10,487,640	G/A	—	uncertain significance
rs776528613	18:10,487,666	C/T	—	likely benign
rs1361536724	18:10,487,667	G/A	—	uncertain significance
rs752888866	18:10,487,685	G/A	—	uncertain significance
rs2510162787	18:10,487,686	G/C	—	uncertain significance
rs1267305223	18:10,487,711	C/T	—	likely benign
rs139112764	18:10,487,720	C/T	—	likely benign
rs114154601	18:10,487,749	C/T	—	likely benign
rs139844939	18:10,487,752	A/T	—	uncertain significance
rs2510162877	18:10,487,777	G/C	—	uncertain significance
rs766126994	18:10,487,781	G/A	—	uncertain significance
rs116143459	18:10,487,784	C/A	—	benign
rs562518496	18:10,487,785	G/A	—	uncertain significance
rs374253239	18:10,487,791	G/A	—	uncertain significance
rs200082076	18:10,487,822	C/A	—	likely benign
rs374423135	18:10,487,825	C/T	—	likely benign
rs749401498	18:10,487,827	G/A	—	uncertain significance
rs142674398	18:10,487,900	G/A	—	likely benign
rs1220087910	18:10,487,902	C/T	—	uncertain significance
rs3185480	18:10,487,918	C/T	—	benign
rs112875590	18:10,487,950	G/A	—	benign
rs1598401716	18:10,487,967	A/G	—	likely benign
rs138401718	18:10,487,974	C/G	—	uncertain significance
rs376533264	18:10,487,990	A/C	—	benign
rs60421789	18:10,487,999	C/T	—	benign

Showing 100 of 102 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.