CALCRL
calcitonin receptor like receptor
Summary
Enables adrenomedullin binding activity; adrenomedullin receptor activity; and calcitonin gene-related peptide receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; cellular response to sucrose stimulus; and receptor internalization. Located in several cellular components, including endoplasmic reticulum; endosome; and lysosome. Part of CGRP receptor complex and adrenomedullin receptor complex. Implicated in hereditary lymphedema. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants38 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs148965095 | 2:188,211,005 | C/A | — | benign |
| rs761424831 | 2:188,211,041 | G/A | — | uncertain significance |
| rs777141533 | 2:188,211,057 | C/T | — | uncertain significance |
| rs858745 | 2:188,216,807 | T/C | — | benign |
| rs2468616999 | 2:188,216,903 | G/T | — | uncertain significance |
| rs144814027 | 2:188,217,029 | G/A | — | uncertain significance |
| rs77035639 | 2:188,220,301 | A/G | intron variant | — |
| rs858753 | 2:188,221,350 | G/T | — | — |
| rs1469505838 | 2:188,223,807 | T/C | — | uncertain significance |
| rs1706287 | 2:188,224,057 | A/G | — | benign |
| rs3815524 | 2:188,224,322 | G/A | — | — |
| rs111617832 | 2:188,225,329 | G/A | — | benign |
| rs778914833 | 2:188,228,130 | G/T | — | uncertain significance |
| rs758306517 | 2:188,228,141 | C/T | — | uncertain significance |
| rs840617 | 2:188,230,333 | A/T | intron variant | — |
| rs16828937 | 2:188,231,433 | T/C | intron variant | — |
| rs858756 | 2:188,233,714 | G/C | intron variant | — |
| rs6759535 | 2:188,238,101 | T/G | — | — |
| rs1687880132 | 2:188,243,710 | T/C | — | uncertain significance |
| rs1363394914 | 2:188,243,752 | G/C | — | uncertain significance |
| rs2468697403 | 2:188,245,190 | A/G | — | likely benign |
| rs61739909 | 2:188,245,439 | A/G | missense variant | — |
| rs757975393 | 2:188,245,512 | C/T | — | likely benign |
| rs2468705690 | 2:188,248,006 | C/G | — | uncertain significance |
| rs751281594 | 2:188,248,022 | G/A | — | likely benign |
| rs3821184 | 2:188,249,420 | G/A | — | — |
| rs1157699 | 2:188,258,904 | C/T | intron variant | — |
| rs75380157 | 2:188,271,085 | A/T | intron variant | — |
| rs10931289 | 2:188,271,819 | C/T | — | — |
| rs6719550 | 2:188,272,460 | C/T | regulatory region variant | — |
| rs111917980 | 2:188,276,584 | G/A | upstream gene variant | — |
| rs67285003 | 2:188,280,896 | C/T | downstream gene variant | — |
| rs11685426 | 2:188,283,061 | G/A | downstream gene variant | — |
| rs13426120 | 2:188,290,969 | A/G | — | — |
| rs11894589 | 2:188,293,391 | C/T | intron variant | — |
| rs574603859 | 2:188,301,544 | A/T | — | — |
| rs1912849 | 2:188,310,118 | A/G | — | — |
| rs147565266 | 2:188,311,515 | T/A | regulatory region variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.