CD86
CD86 molecule
Summary
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]
Known Variants31 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2681411 | 3:121,785,631 | G/A | intron variant | — |
| rs4308217 | 3:121,793,187 | C/T | — | — |
| rs10511408 | 3:121,793,508 | T/C | regulatory region variant | — |
| rs9282641 | 3:121,796,768 | G/A | regulatory region variant | — |
| rs9831894 | 3:121,800,487 | A/C | regulatory region variant | — |
| rs143648885 | 3:121,804,254 | G/T | intron variant | — |
| rs113267846 | 3:121,820,906 | C/A | — | — |
| rs149667487 | 3:121,822,365 | C/T | — | uncertain significance |
| rs769924675 | 3:121,822,511 | G/C | — | uncertain significance |
| rs146192611 | 3:121,822,512 | A/G | — | uncertain significance |
| rs771290530 | 3:121,822,524 | G/A | — | likely benign |
| rs35276006 | 3:121,822,541 | A/G | — | uncertain significance |
| rs969643514 | 3:121,822,688 | G/A | — | uncertain significance |
| rs200437316 | 3:121,825,068 | G/T | — | uncertain significance |
| rs773419046 | 3:121,825,096 | T/C | — | uncertain significance |
| rs760371523 | 3:121,825,098 | T/C | — | uncertain significance |
| rs766044307 | 3:121,825,101 | A/C | — | uncertain significance |
| rs2473000775 | 3:121,825,152 | A/G | — | uncertain significance |
| rs143957877 | 3:121,825,195 | G/T | — | uncertain significance |
| rs771222249 | 3:121,825,255 | C/G | — | uncertain significance |
| rs772981720 | 3:121,825,321 | G/A | — | likely benign |
| rs73858127 | 3:121,827,743 | G/T | — | — |
| rs2473007460 | 3:121,828,228 | A/C | — | uncertain significance |
| rs373228315 | 3:121,828,232 | G/A | — | likely benign |
| rs750874477 | 3:121,828,238 | G/A | — | uncertain significance |
| rs376063335 | 3:121,838,310 | T/G | — | uncertain significance |
| rs1129055 | 3:121,838,319 | G/A | missense variant | benign |
| rs201148004 | 3:121,838,325 | C/T | — | likely benign |
| rs370380261 | 3:121,838,326 | G/A | — | likely benign |
| rs9282648 | 3:121,838,358 | G/A | — | benign |
| rs17281995 | 3:121,839,641 | G/C | 3 prime UTR variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.