CDC37
cell division cycle 37, HSP90 cochaperone
Summary
The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008]
Known Variants17 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1214056374 | 19:10,502,267 | G/A | — | uncertain significance |
| rs775595344 | 19:10,502,318 | C/T | — | uncertain significance |
| rs757086543 | 19:10,503,815 | C/A | — | uncertain significance |
| rs140381502 | 19:10,503,947 | C/T | — | benign |
| rs145608201 | 19:10,503,961 | C/T | — | benign |
| rs149499190 | 19:10,503,996 | C/T | — | uncertain significance |
| rs780606412 | 19:10,504,048 | G/A | — | uncertain significance |
| rs147547295 | 19:10,505,783 | T/C | — | uncertain significance |
| rs866354313 | 19:10,506,011 | G/A | — | uncertain significance |
| rs61747102 | 19:10,506,145 | G/A | — | benign |
| rs145251489 | 19:10,506,704 | T/C | — | uncertain significance |
| rs150997404 | 19:10,506,707 | C/A | — | uncertain significance |
| rs749556906 | 19:10,506,725 | G/A | — | uncertain significance |
| rs2231483 | 19:10,506,814 | C/G | — | uncertain significance |
| rs11879191 | 19:10,512,911 | G/C | — | — |
| rs2512433811 | 19:10,514,095 | G/A | — | uncertain significance |
| rs2569788 | 19:10,514,159 | G/C | coding sequence variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.