DACH1
dachshund family transcription factor 1
Summary
This gene encodes a chromatin-associated protein that associates with other DNA-binding transcription factors to regulate gene expression and cell fate determination during development. The protein contains a Ski domain that is highly conserved from Drosophila to human. Expression of this gene is lost in some forms of metastatic cancer, and is correlated with poor prognosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Known Variants49 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs9285274 | 13:72,014,034 | C/T | 3 prime UTR variant | — |
| rs9529895 | 13:72,014,070 | C/T | 3 prime UTR variant | — |
| rs2501351562 | 13:72,014,791 | T/C | — | uncertain significance |
| rs9599848 | 13:72,048,096 | A/T | — | — |
| rs766451935 | 13:72,049,979 | T/C | — | uncertain significance |
| rs2501516581 | 13:72,053,366 | A/C | — | uncertain significance |
| rs192675802 | 13:72,063,123 | G/A | — | conflicting classifications of pathogenicity |
| rs375317673 | 13:72,063,153 | G/C | — | uncertain significance |
| rs369796985 | 13:72,063,155 | T/C | — | uncertain significance |
| rs751897642 | 13:72,063,254 | C/T | — | uncertain significance |
| rs369734188 | 13:72,131,164 | A/G | — | uncertain significance |
| rs374225059 | 13:72,131,234 | C/T | — | uncertain significance |
| rs372169081 | 13:72,133,997 | C/T | — | uncertain significance |
| rs773857283 | 13:72,134,081 | C/A | — | uncertain significance |
| rs1192436758 | 13:72,134,083 | C/T | — | uncertain significance |
| rs9919839 | 13:72,174,353 | C/T | intron variant | — |
| rs17088351 | 13:72,197,564 | C/T | intron variant | — |
| rs59352399 | 13:72,200,663 | C/T | regulatory region variant | — |
| rs144078930 | 13:72,204,689 | G/C | — | benign |
| rs2502093067 | 13:72,204,802 | T/C | — | uncertain significance |
| rs375785303 | 13:72,255,933 | G/A | — | uncertain significance |
| rs1185541308 | 13:72,256,005 | C/T | — | uncertain significance |
| rs374769182 | 13:72,340,241 | G/A | — | — |
| rs7331398 | 13:72,340,262 | T/A | — | — |
| rs1325345 | 13:72,344,596 | A/C | — | — |
| rs4884958 | 13:72,345,448 | G/A | — | — |
| rs584480 | 13:72,345,505 | C/A | — | — |
| rs478141 | 13:72,346,092 | G/A | intron variant | — |
| rs626277 | 13:72,347,696 | A/C | intron variant | — |
| rs9318029 | 13:72,365,249 | C/T | intron variant | — |
| rs487107 | 13:72,369,159 | G/T | intron variant | — |
| rs9572790 | 13:72,370,966 | T/C | — | — |
| rs303937 | 13:72,372,524 | T/A | intron variant | — |
| rs2501892818 | 13:72,440,333 | A/G | — | uncertain significance |
| rs529808627 | 13:72,440,339 | C/T | — | uncertain significance |
| rs781663055 | 13:72,440,375 | G/T | — | uncertain significance |
| rs1278114853 | 13:72,440,378 | G/A | — | uncertain significance |
| rs1383549766 | 13:72,440,482 | G/C | — | uncertain significance |
| rs942180060 | 13:72,440,555 | C/G | — | uncertain significance |
| rs755013564 | 13:72,440,564 | T/G | — | uncertain significance |
| rs1051896039 | 13:72,440,576 | G/A | — | uncertain significance |
| rs772273600 | 13:72,440,580 | G/C | — | uncertain significance |
| rs1247638734 | 13:72,440,646 | C/T | — | uncertain significance |
| rs1874828890 | 13:72,440,717 | G/A | — | uncertain significance |
| rs774997411 | 13:72,440,738 | G/C | — | uncertain significance |
| rs1454125799 | 13:72,440,778 | T/C | — | uncertain significance |
| rs201008975 | 13:72,440,801 | G/A | — | uncertain significance |
| rs1351443893 | 13:72,440,861 | G/C | — | uncertain significance |
| rs2501902268 | 13:72,440,876 | G/C | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.