DGCR8
DGCR8 microprocessor complex subunit
Summary
This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
Known Variants70 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs368705994 | 22:20,073,519 | G/A | — | likely benign |
| rs140782334 | 22:20,073,529 | G/A | — | uncertain significance |
| rs201011065 | 22:20,073,560 | G/A | — | uncertain significance |
| rs1346293099 | 22:20,073,563 | C/G | — | uncertain significance |
| rs111669527 | 22:20,073,564 | C/T | — | likely benign |
| rs776415767 | 22:20,073,572 | C/T | — | uncertain significance |
| rs762505368 | 22:20,073,580 | C/T | — | uncertain significance |
| rs1298133990 | 22:20,073,683 | C/G | — | uncertain significance |
| rs1356566625 | 22:20,073,695 | A/G | — | uncertain significance |
| rs1311745193 | 22:20,073,737 | G/A | — | uncertain significance |
| rs755158789 | 22:20,073,774 | G/A | — | likely benign |
| rs775155216 | 22:20,073,792 | A/G | — | likely benign |
| rs377706846 | 22:20,073,824 | A/G | — | uncertain significance |
| rs372483452 | 22:20,073,861 | C/T | — | likely benign |
| rs370350957 | 22:20,073,915 | C/T | — | likely benign |
| rs192598875 | 22:20,073,924 | G/A | — | likely benign |
| rs138332207 | 22:20,073,930 | C/T | — | benign |
| rs536949587 | 22:20,073,996 | C/T | — | likely benign |
| rs555922599 | 22:20,074,000 | G/T | — | uncertain significance |
| rs199753950 | 22:20,074,090 | T/G | — | uncertain significance |
| rs2519264260 | 22:20,074,166 | G/T | — | uncertain significance |
| rs7291552 | 22:20,074,699 | C/T | — | benign |
| rs765820841 | 22:20,074,785 | C/T | — | uncertain significance |
| rs201393758 | 22:20,074,819 | G/C | — | uncertain significance |
| rs117148342 | 22:20,076,642 | G/A | downstream gene variant | — |
| rs779520821 | 22:20,077,504 | C/T | — | likely benign |
| rs143390902 | 22:20,077,566 | G/A | — | likely benign |
| rs145885136 | 22:20,077,575 | G/A | — | likely benign |
| rs372247721 | 22:20,077,595 | G/A | — | uncertain significance |
| rs778778919 | 22:20,077,610 | G/A | — | uncertain significance |
| rs759958934 | 22:20,077,642 | G/C | — | uncertain significance |
| rs2049537239 | 22:20,077,686 | C/T | — | uncertain significance |
| rs560910865 | 22:20,077,689 | C/G | — | uncertain significance |
| rs34204101 | 22:20,077,720 | A/C | — | benign |
| rs113891618 | 22:20,077,756 | C/T | — | benign |
| rs1568954479 | 22:20,077,757 | G/A | — | uncertain significance |
| rs777348779 | 22:20,077,778 | G/A | — | uncertain significance |
| rs142497183 | 22:20,078,948 | T/C | — | likely benign |
| rs369018600 | 22:20,078,990 | C/T | — | uncertain significance |
| rs780683557 | 22:20,079,013 | T/C | — | likely benign |
| rs750868057 | 22:20,079,014 | G/C | — | uncertain significance |
| rs779151479 | 22:20,079,068 | C/T | — | uncertain significance |
| rs1383866685 | 22:20,079,069 | G/A | — | uncertain significance |
| rs772124676 | 22:20,079,079 | G/C | — | likely benign |
| rs149336675 | 22:20,079,084 | C/G | — | uncertain significance |
| rs780692891 | 22:20,079,423 | G/A | — | likely benign |
| rs11089328 | 22:20,079,603 | A/T | — | — |
| rs2049582461 | 22:20,080,412 | C/T | — | uncertain significance |
| rs192456461 | 22:20,080,839 | A/C | intron variant | — |
| rs376917266 | 22:20,082,229 | T/C | — | likely benign |
| rs2519281055 | 22:20,082,284 | C/G | — | uncertain significance |
| rs35569747 | 22:20,082,293 | A/G | — | likely benign |
| rs9606250 | 22:20,090,192 | A/T | intron variant | — |
| rs1633418 | 22:20,091,756 | T/G | — | — |
| rs112367533 | 22:20,091,833 | G/A | intron variant | — |
| rs145970507 | 22:20,093,738 | C/T | — | likely benign |
| rs201892577 | 22:20,094,185 | G/C | — | uncertain significance |
| rs139842996 | 22:20,094,193 | G/A | — | likely benign |
| rs1234973935 | 22:20,094,806 | G/A | — | uncertain significance |
| rs146678770 | 22:20,094,825 | C/T | — | likely benign |
| rs773783409 | 22:20,094,896 | G/A | — | uncertain significance |
| rs7364132 | 22:20,096,172 | G/A | regulatory region variant | — |
| rs201476247 | 22:20,097,575 | T/A | — | uncertain significance |
| rs750484563 | 22:20,097,580 | T/C | — | likely benign |
| rs148884257 | 22:20,097,585 | C/T | — | conflicting classifications of pathogenicity |
| rs765113050 | 22:20,097,586 | G/A | — | likely benign |
| rs997639108 | 22:20,097,601 | C/T | — | likely benign |
| rs200972698 | 22:20,097,602 | G/A | — | uncertain significance |
| rs1640299 | 22:20,098,359 | T/G | coding sequence variant | — |
| rs417309 | 22:20,098,544 | G/A | coding sequence variant | benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.