DKKL1
dickkopf like acrosomal protein 1
Summary
The dickkopf protein family interacts with the Wnt signaling pathway and its members are characterized by two conserved cysteine-rich domains. This gene encodes a secreted protein that has low sequence similarity to the dickkopf-3 protein. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
Known Variants27 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs748281161 | 19:49,867,893 | C/T | — | uncertain significance |
| rs771111490 | 19:49,867,998 | G/T | — | uncertain significance |
| rs975413217 | 19:49,868,789 | C/G | — | uncertain significance |
| rs537755411 | 19:49,868,799 | T/G | — | uncertain significance |
| rs749502791 | 19:49,868,876 | C/A | — | uncertain significance |
| rs774183266 | 19:49,868,881 | T/A | — | uncertain significance |
| rs2303759 | 19:49,869,051 | T/G | missense variant | benign |
| rs1973227998 | 19:49,869,069 | G/A | — | uncertain significance |
| rs756989658 | 19:49,869,099 | C/A | — | uncertain significance |
| rs771662943 | 19:49,869,114 | C/T | — | uncertain significance |
| rs761509338 | 19:49,869,126 | T/C | — | uncertain significance |
| rs187172633 | 19:49,872,470 | G/A | coding sequence variant | — |
| rs55809481 | 19:49,872,521 | T/C | coding sequence variant | — |
| rs142140365 | 19:49,874,269 | A/G | coding sequence variant | — |
| rs567208378 | 19:49,875,592 | C/T | — | — |
| rs186118539 | 19:49,875,778 | G/A | intron variant | — |
| rs183059322 | 19:49,877,060 | C/T | intron variant | — |
| rs1232681822 | 19:49,877,994 | G/T | — | uncertain significance |
| rs111233735 | 19:49,878,053 | G/A | — | benign |
| rs766186744 | 19:49,878,062 | T/C | — | uncertain significance |
| rs530435433 | 19:49,878,085 | C/T | — | uncertain significance |
| rs750220074 | 19:49,878,143 | G/A | — | uncertain significance |
| rs771662060 | 19:49,878,170 | G/A | — | uncertain significance |
| rs953466250 | 19:49,878,172 | A/G | — | likely benign |
| rs1405855667 | 19:49,878,202 | G/T | — | uncertain significance |
| rs551864261 | 19:49,878,250 | T/G | — | uncertain significance |
| rs35389403 | 19:49,878,275 | G/A | — | benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.