DOCK4

dedicator of cytokinesis 4

Summary

This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized. [provided by RefSeq, Jul 2008]

Known Variants130 total

rsidPosition (GRCh37)AllelesClassClinVar
rs12437622037:111,368,345C/A—uncertain significance
rs7781815537:111,368,350G/A—uncertain significance
rs7740432307:111,368,385C/T—uncertain significance
rs9696123897:111,368,389G/A—uncertain significance
rs15857936097:111,368,444G/A—likely benign
rs345974397:111,368,454G/A—benign
rs1997063467:111,368,481G/A—likely benign
rs5495779167:111,368,520C/T—likely benign
rs7568666847:111,368,526G/A—uncertain significance
rs3717546357:111,368,691T/C—uncertain significance
rs15634151397:111,368,752A/G—uncertain significance
rs7760530967:111,368,754G/A—uncertain significance
rs102819427:111,368,767G/T—benign
rs3776834367:111,372,299C/T—uncertain significance
rs5596794337:111,372,301G/A—uncertain significance
rs7664231357:111,372,313G/T—uncertain significance
rs2011195947:111,372,325G/A—uncertain significance
rs12226007317:111,375,111A/T—likely benign
rs7468092697:111,375,140G/A—uncertain significance
rs7697315087:111,375,163G/A—uncertain significance
rs15634261317:111,375,179C/G—uncertain significance
rs9213935917:111,375,214G/A—uncertain significance
rs14183642427:111,375,215G/A—uncertain significance
rs3701791807:111,379,235C/G—uncertain significance
rs7469883117:111,381,662C/T—uncertain significance
rs3764047697:111,382,095C/T—uncertain significance
rs37576507:111,382,130C/T—benign
rs1474143537:111,387,371A/G—benign
rs3712509547:111,387,457T/G—uncertain significance
rs3748308207:111,387,495T/C—uncertain significance
rs25362887457:111,387,501T/C—uncertain significance
rs2010306567:111,395,602G/C—uncertain significance
rs25363546217:111,395,657T/C—uncertain significance
rs14833645397:111,398,723C/T—uncertain significance
rs25363813317:111,398,768T/C—uncertain significance
rs3708154637:111,398,794C/T—likely benign
rs7811443847:111,400,325T/C—likely benign
rs15858995927:111,400,336C/G—uncertain significance
rs3714647267:111,400,359C/T—uncertain significance
rs7792922717:111,407,124C/G—uncertain significance
rs13324233617:111,407,130C/A—uncertain significance
rs1401154137:111,409,621C/A—benign
rs14013151617:111,409,635G/A—uncertain significance
rs12842492607:111,409,682C/T—uncertain significance
rs3725976517:111,418,336A/C—uncertain significance
rs7707925877:111,418,364T/C—uncertain significance
rs7608257377:111,423,988C/T—uncertain significance
rs7793433997:111,430,603C/A—uncertain significance
rs17994586677:111,430,628A/G—likely pathogenic
rs1997754247:111,430,652T/C—uncertain significance
rs2009036847:111,430,661C/T—likely benign
rs25367685447:111,448,912A/G—likely pathogenic
rs25367685897:111,448,918A/G—uncertain significance
rs25367687937:111,448,931C/T—uncertain significance
rs1924829627:111,449,381G/T—likely benign
rs3763940797:111,449,434G/A—likely benign
rs20741147:111,451,659T/Cintron variant—
rs7776188087:111,451,956A/G—uncertain significance
rs9573735277:111,451,970G/C—uncertain significance
rs25367985457:111,451,991G/A—likely pathogenic
rs3736186687:111,451,999A/G—likely benign
rs3766605667:111,452,001T/C—uncertain significance
rs7512332657:111,462,466G/A—uncertain significance
rs1860310927:111,462,470G/T—likely benign
rs7493323547:111,462,481C/T—uncertain significance
rs12590983987:111,462,497T/C—uncertain significance
rs25369680057:111,474,648A/T—uncertain significance
rs5438385567:111,474,708C/T—uncertain significance
rs18030940817:111,474,709G/A—uncertain significance
rs1415615097:111,475,436T/Aregulatory region variant—
rs25370412427:111,484,866G/A—uncertain significance
rs15862054897:111,503,489C/T—likely benign
rs7622553357:111,503,559C/T—uncertain significance
rs7533754117:111,503,565T/C—uncertain significance
rs7636513777:111,508,073C/G—uncertain significance
rs25372216477:111,508,130C/G—uncertain significance
rs3676264117:111,509,658C/A—uncertain significance
rs3718517937:111,509,676C/T—uncertain significance
rs14264138787:111,509,720C/T—likely benign
rs7396177:111,510,866C/Tintron variant—
rs102243267:111,512,032A/T—benign
rs25372626277:111,512,094A/G—uncertain significance
rs3708139597:111,517,115A/G—uncertain significance
rs13637456477:111,517,131A/G—uncertain significance
rs12189279227:111,517,133G/A—uncertain significance
rs7500465267:111,517,181C/A—uncertain significance
rs127058017:111,517,227T/C—likely benign
rs102552997:111,527,560G/T——
rs1114453957:111,527,824A/T——
rs1162087017:111,540,494T/C—benign
rs7616594757:111,540,583A/C—uncertain significance
rs7488138237:111,541,770G/A—uncertain significance
rs7681651937:111,541,792C/T—uncertain significance
rs14081882077:111,541,812A/T—uncertain significance
rs3759838457:111,555,873T/A—uncertain significance
rs1897595107:111,555,931G/A—likely benign
rs2014119397:111,555,943T/C—benign
rs5749957917:111,565,966C/A——
rs5359435377:111,565,968C/A——
rs7642780487:111,580,226G/C—uncertain significance

Showing 100 of 130 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.