DPP9
dipeptidyl peptidase 9
Summary
This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. The protein has been shown to have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Although the activity of this protein is similar to that of dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane bound. In general, dipeptidyl peptidases appear to be involved in the regulation of the activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. Several transcript variants of this gene have been described but not fully characterized. [provided by RefSeq, Jul 2008]
Known Variants80 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2512344317 | 19:4,679,882 | G/A | — | pathogenic |
| rs376836687 | 19:4,679,939 | G/A | — | uncertain significance |
| rs1021615821 | 19:4,682,757 | C/T | — | uncertain significance |
| rs772798495 | 19:4,682,778 | C/T | — | uncertain significance |
| rs761296885 | 19:4,682,823 | C/T | — | uncertain significance |
| rs775362476 | 19:4,683,600 | G/T | — | uncertain significance |
| rs2512452730 | 19:4,684,734 | C/T | — | uncertain significance |
| rs748102598 | 19:4,684,782 | A/G | — | likely benign |
| rs778792324 | 19:4,685,646 | C/T | — | uncertain significance |
| rs187881686 | 19:4,685,724 | G/A | — | uncertain significance |
| rs772251728 | 19:4,685,736 | G/A | — | uncertain significance |
| rs767001811 | 19:4,685,777 | G/A | — | uncertain significance |
| rs369048539 | 19:4,688,799 | G/T | — | uncertain significance |
| rs372503424 | 19:4,688,820 | C/T | — | uncertain significance |
| rs187026346 | 19:4,688,830 | G/T | — | benign |
| rs1168111742 | 19:4,688,850 | G/A | — | uncertain significance |
| rs371079050 | 19:4,688,871 | C/T | — | uncertain significance |
| rs1026379140 | 19:4,689,590 | T/C | — | uncertain significance |
| rs1375584889 | 19:4,689,599 | T/A | — | uncertain significance |
| rs2091125008 | 19:4,689,625 | C/T | — | uncertain significance |
| rs200229921 | 19:4,689,635 | C/T | — | likely benign |
| rs370177829 | 19:4,689,638 | C/T | — | uncertain significance |
| rs2512545102 | 19:4,689,706 | A/C | — | uncertain significance |
| rs201281354 | 19:4,690,960 | T/C | — | uncertain significance |
| rs1439738491 | 19:4,694,703 | C/T | — | uncertain significance |
| rs943100305 | 19:4,694,730 | T/C | — | uncertain significance |
| rs956480506 | 19:4,694,758 | C/A | — | uncertain significance |
| rs760332782 | 19:4,694,790 | C/G | — | uncertain significance |
| rs747191146 | 19:4,694,831 | T/A | — | uncertain significance |
| rs148018996 | 19:4,695,485 | C/G | — | likely benign |
| rs2512667721 | 19:4,695,487 | G/A | — | uncertain significance |
| rs1476509154 | 19:4,695,513 | G/C | — | likely benign |
| rs774865262 | 19:4,695,521 | C/T | — | uncertain significance |
| rs541362049 | 19:4,695,557 | T/C | — | uncertain significance |
| rs756303433 | 19:4,697,575 | C/T | — | uncertain significance |
| rs981730364 | 19:4,697,588 | C/A | — | uncertain significance |
| rs75029446 | 19:4,701,727 | C/T | regulatory region variant | — |
| rs756602514 | 19:4,702,054 | G/A | — | uncertain significance |
| rs148904342 | 19:4,702,065 | G/A | — | benign |
| rs74793100 | 19:4,702,085 | A/G | — | benign |
| rs764719635 | 19:4,702,123 | C/T | — | uncertain significance |
| rs889208791 | 19:4,702,129 | C/G | — | uncertain significance |
| rs750693651 | 19:4,702,149 | G/A | — | uncertain significance |
| rs769162859 | 19:4,702,678 | C/T | — | uncertain significance |
| rs2512845528 | 19:4,703,901 | G/T | — | likely benign |
| rs2512845714 | 19:4,703,909 | A/T | — | uncertain significance |
| rs373451371 | 19:4,703,921 | C/T | — | conflicting classifications of pathogenicity |
| rs199621774 | 19:4,703,922 | G/A | — | uncertain significance |
| rs372689637 | 19:4,703,937 | C/T | — | uncertain significance |
| rs761600246 | 19:4,703,960 | C/T | — | likely benign |
| rs1035828922 | 19:4,704,023 | C/G | — | uncertain significance |
| rs2092446218 | 19:4,704,026 | G/C | — | conflicting classifications of pathogenicity |
| rs778385795 | 19:4,704,160 | C/A | — | uncertain significance |
| rs1480394147 | 19:4,704,163 | C/T | — | uncertain significance |
| rs187492097 | 19:4,704,164 | G/A | — | benign |
| rs201569823 | 19:4,704,168 | C/A | — | uncertain significance |
| rs200878232 | 19:4,704,192 | G/C | — | likely benign |
| rs377360311 | 19:4,704,229 | C/T | — | uncertain significance |
| rs1193951296 | 19:4,704,244 | C/T | — | conflicting classifications of pathogenicity |
| rs779854175 | 19:4,705,965 | G/A | — | pathogenic |
| rs780976744 | 19:4,705,974 | A/G | — | uncertain significance |
| rs1399825957 | 19:4,714,107 | C/T | — | uncertain significance |
| rs764661019 | 19:4,714,111 | G/A | — | uncertain significance |
| rs2092965148 | 19:4,714,125 | G/T | — | uncertain significance |
| rs1445507040 | 19:4,714,149 | T/C | — | uncertain significance |
| rs192960415 | 19:4,714,157 | G/A | — | benign |
| rs200324423 | 19:4,714,163 | C/T | — | likely benign |
| rs374165392 | 19:4,714,164 | G/A | — | uncertain significance |
| rs769344750 | 19:4,714,185 | G/A | — | uncertain significance |
| rs761956128 | 19:4,714,195 | G/A | — | uncertain significance |
| rs1391506545 | 19:4,714,230 | G/A | — | uncertain significance |
| rs1327602192 | 19:4,714,235 | C/G | — | uncertain significance |
| rs558641911 | 19:4,714,279 | C/T | — | likely benign |
| rs755414812 | 19:4,714,296 | G/A | — | uncertain significance |
| rs749337868 | 19:4,714,308 | G/A | — | uncertain significance |
| rs1315809181 | 19:4,714,327 | C/A | — | uncertain significance |
| rs776335771 | 19:4,714,344 | G/A | — | uncertain significance |
| rs202179513 | 19:4,714,353 | C/T | — | likely benign |
| rs12610495 | 19:4,717,672 | A/G | regulatory region variant | — |
| rs771615957 | 19:4,719,914 | C/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.