rs12610495

This is a regulatory region variant variant in the DPP9 gene.

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GWAS Catalog Trait Associations (5)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

COVID-19

Diz-de Almeida S et al. “Novel risk loci for COVID-19 hospitalization among admixed American populations.” Elife 13 (2024)
Allele A
OR 0.15
p 2.0e-53
N 73,303
Large GWAS
multi-ancestry
Pairo-Castineira E et al. “GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19.” Nature 617(7962):764-768 (2023)
Allele A
OR 0.80
p 9.0e-51
N 1,779,771
Meta-analysisLarge GWAS
multi-ancestry
Kousathanas A et al. “Whole-genome sequencing reveals host factors underlying critical COVID-19.” Nature 607(7917):97-103 (2022)
Allele A
OR 1.30
p 4.0e-36
N 48,880
Large GWAS
European

body height

Yengo L et al. “A saturated map of common genetic variants associated with human height.” Nature 610(7933):704-712 (2022)
Allele G
OR 0.01
p 2.0e-32
N 5,314,291
Large GWAS
European, Hispanic or Latin American, East Asian, African unspecified, South Asian

idiopathic pulmonary fibrosis

Allen RJ et al. “Genome-wide association study across five cohorts identifies five novel loci associated with idiopathic pulmonary fibrosis.” Thorax 77(8):829-833 (2022)
Allele G
OR 1.28
p 3.0e-16
N 24,589
Large GWAS
European
Allen RJ et al. “Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis.” American Journal of Respiratory and Critical Care Medicine 201(5):564-574 (2020)
Allele G
OR 1.31
p 3.0e-12
N 11,259
Large GWAS
European

interstitial lung disease

Fingerlin TE et al. “Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis.” Nature Genetics 45(6):613-20 (2013)
Allele G
OR 1.29
p 2.0e-12
N 5,844
Large GWAS
European

respiratory failure, COVID-19

Degenhardt F et al. “Detailed stratified GWAS analysis for severe COVID-19 in four European populations.” Human Molecular Genetics 31(23):3945-3966 (2022)
Allele G
OR 1.29
p 3.0e-8
N 14,137
Large GWAS
European

About DPP9

This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. The protein has been shown to have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Although the activity of this protein is similar to that of dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane bound. In general, dipeptidyl peptidases appear to be involved in the regulation of the activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. Several transcript variants of this gene have been described but not fully characterized. [provided by RefSeq, Jul 2008]

View all DPP9 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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