FES
FES proto-oncogene, tyrosine kinase
Summary
This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.[provided by RefSeq, Jan 2009]
Known Variants58 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs4702 | 15:91,426,560 | G/C | — | — |
| rs12906125 | 15:91,427,612 | G/A | regulatory region variant | — |
| rs370302986 | 15:91,428,289 | C/T | — | uncertain significance |
| rs139960065 | 15:91,428,360 | G/C | — | uncertain significance |
| rs1433928878 | 15:91,428,452 | G/C | — | uncertain significance |
| rs7183988 | 15:91,428,589 | T/G | regulatory region variant | — |
| rs985996027 | 15:91,428,673 | G/A | — | uncertain significance |
| rs1894400 | 15:91,428,955 | C/T | regulatory region variant | — |
| rs1894401 | 15:91,429,042 | G/A | regulatory region variant | — |
| rs4932373 | 15:91,429,287 | A/C | regulatory region variant | — |
| rs372642630 | 15:91,430,264 | G/A | — | uncertain significance |
| rs761499946 | 15:91,430,282 | G/A | — | uncertain significance |
| rs1248269225 | 15:91,430,506 | G/C | — | uncertain significance |
| rs769777721 | 15:91,430,536 | C/G | — | uncertain significance |
| rs377603197 | 15:91,430,552 | G/A | — | uncertain significance |
| rs2071384 | 15:91,430,617 | G/A | downstream gene variant | — |
| rs4533264 | 15:91,431,524 | T/C | downstream gene variant | — |
| rs1390376014 | 15:91,432,542 | G/C | — | uncertain significance |
| rs762267346 | 15:91,432,591 | G/T | — | uncertain significance |
| rs145351114 | 15:91,432,628 | G/A | — | uncertain significance |
| rs769033143 | 15:91,432,664 | G/A | — | likely benign |
| rs765947794 | 15:91,432,751 | G/A | — | likely benign |
| rs752463620 | 15:91,432,776 | C/T | — | uncertain significance |
| rs148753998 | 15:91,432,800 | A/G | — | uncertain significance |
| rs56296062 | 15:91,433,110 | A/G | — | benign |
| rs149066819 | 15:91,433,138 | C/T | — | uncertain significance |
| rs955842955 | 15:91,433,164 | G/A | — | uncertain significance |
| rs1474696039 | 15:91,433,169 | G/T | — | uncertain significance |
| rs371311890 | 15:91,433,185 | C/G | — | uncertain significance |
| rs183173261 | 15:91,433,190 | G/C | — | uncertain significance |
| rs760846247 | 15:91,433,381 | C/T | — | uncertain significance |
| rs201841209 | 15:91,433,507 | C/T | — | uncertain significance |
| rs147101703 | 15:91,433,645 | G/T | — | uncertain significance |
| rs575070040 | 15:91,433,650 | G/A | — | uncertain significance |
| rs1417576519 | 15:91,433,662 | C/T | — | uncertain significance |
| rs776230369 | 15:91,434,237 | C/T | — | uncertain significance |
| rs56387260 | 15:91,434,268 | G/A | — | benign |
| rs2505738508 | 15:91,434,272 | T/C | — | uncertain significance |
| rs774122108 | 15:91,434,287 | C/A | — | uncertain significance |
| rs2505744443 | 15:91,434,880 | G/A | — | likely benign |
| rs1002243837 | 15:91,434,895 | G/C | — | uncertain significance |
| rs767272194 | 15:91,435,971 | G/A | — | uncertain significance |
| rs62640875 | 15:91,435,993 | G/A | — | benign |
| rs2505760049 | 15:91,436,388 | A/G | — | uncertain significance |
| rs2505760211 | 15:91,436,401 | A/C | — | uncertain significance |
| rs775363239 | 15:91,436,403 | A/G | — | uncertain significance |
| rs149647375 | 15:91,436,521 | G/C | — | uncertain significance |
| rs143228307 | 15:91,436,525 | C/A | — | likely benign |
| rs779752765 | 15:91,436,545 | G/T | — | uncertain significance |
| rs967470597 | 15:91,436,553 | G/T | — | uncertain significance |
| rs777821171 | 15:91,436,897 | C/T | — | uncertain significance |
| rs2033454157 | 15:91,436,972 | G/T | — | uncertain significance |
| rs751309645 | 15:91,437,168 | C/T | — | uncertain significance |
| rs1441280396 | 15:91,437,225 | A/G | — | uncertain significance |
| rs2521501 | 15:91,437,388 | A/C | — | — |
| rs375467412 | 15:91,438,651 | C/T | — | uncertain significance |
| rs202150302 | 15:91,438,783 | C/T | — | uncertain significance |
| rs757875652 | 15:91,438,784 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.