FGF7
fibroblast growth factor 7
Summary
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis. [provided by RefSeq, Jul 2008]
Known Variants11 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2508096901 | 15:49,716,570 | G/T | — | uncertain significance |
| rs2508097280 | 15:49,716,574 | C/G | — | uncertain significance |
| rs758913734 | 15:49,716,601 | C/T | — | uncertain significance |
| rs10519225 | 15:49,720,778 | G/A | intron variant | — |
| rs12439429 | 15:49,734,634 | C/T | intron variant | — |
| rs9920722 | 15:49,735,112 | C/G | — | — |
| rs4338740 | 15:49,735,297 | T/C | intron variant | — |
| rs17400427 | 15:49,741,071 | T/C | intron variant | — |
| rs10519227 | 15:49,746,364 | T/A | intron variant | — |
| rs7170426 | 15:49,751,853 | A/G | intron variant | — |
| rs2509427511 | 15:49,776,655 | A/C | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.