GRB10
growth factor receptor bound protein 10
Summary
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]
Known Variants73 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs777488599 | 7:50,660,776 | G/A | — | likely benign |
| rs3807550 | 7:50,660,787 | G/A | — | benign |
| rs2535830253 | 7:50,663,148 | A/T | — | uncertain significance |
| rs12540874 | 7:50,664,922 | A/G | intron variant | — |
| rs201369855 | 7:50,671,714 | G/C | — | likely benign |
| rs61756585 | 7:50,671,754 | G/A | — | benign |
| rs79207373 | 7:50,671,792 | G/A | — | benign |
| rs978311592 | 7:50,672,061 | C/T | — | uncertain significance |
| rs371741953 | 7:50,672,977 | G/A | — | likely benign |
| rs752934297 | 7:50,673,030 | G/A | — | uncertain significance |
| rs200010618 | 7:50,673,032 | C/T | — | likely benign |
| rs201569948 | 7:50,673,111 | G/A | — | likely benign |
| rs61734187 | 7:50,674,043 | C/T | — | benign |
| rs770873375 | 7:50,680,473 | T/C | — | uncertain significance |
| rs370043368 | 7:50,682,476 | G/A | — | likely benign |
| rs758525378 | 7:50,682,484 | G/A | — | likely benign |
| rs1375856337 | 7:50,682,532 | T/C | — | likely benign |
| rs1185896001 | 7:50,683,975 | A/T | — | uncertain significance |
| rs1463141448 | 7:50,683,987 | G/C | — | uncertain significance |
| rs376650644 | 7:50,683,997 | A/G | — | likely benign |
| rs369932453 | 7:50,685,815 | C/T | — | uncertain significance |
| rs2190500 | 7:50,686,108 | G/A | — | — |
| rs1800505 | 7:50,686,897 | G/A | — | likely benign |
| rs2053010597 | 7:50,694,603 | G/C | — | uncertain significance |
| rs373879165 | 7:50,694,609 | T/C | — | uncertain significance |
| rs2237442 | 7:50,698,549 | A/C | — | — |
| rs2237457 | 7:50,726,144 | C/T | intron variant | — |
| rs2529415 | 7:50,736,662 | C/T | intron variant | — |
| rs373109707 | 7:50,737,441 | G/A | — | uncertain significance |
| rs778877926 | 7:50,737,456 | G/A | — | uncertain significance |
| rs772708204 | 7:50,737,459 | G/A | — | uncertain significance |
| rs2060174416 | 7:50,737,466 | C/A | — | uncertain significance |
| rs200175899 | 7:50,737,469 | G/T | — | uncertain significance |
| rs772890514 | 7:50,737,472 | G/C | — | uncertain significance |
| rs545374195 | 7:50,737,474 | C/G | — | uncertain significance |
| rs2537869913 | 7:50,737,480 | G/A | — | uncertain significance |
| rs377679652 | 7:50,737,558 | C/T | — | uncertain significance |
| rs2529414 | 7:50,737,831 | G/T | — | — |
| rs73116822 | 7:50,737,852 | C/T | intron variant | — |
| rs2244479 | 7:50,738,987 | C/G | — | — |
| rs17152083 | 7:50,739,610 | G/C | intron variant | — |
| rs73116829 | 7:50,739,738 | G/A | intron variant | — |
| rs73116888 | 7:50,740,960 | C/T | intron variant | — |
| rs752056748 | 7:50,742,141 | G/A | — | likely benign |
| rs756517889 | 7:50,742,163 | C/T | — | uncertain significance |
| rs73697054 | 7:50,742,227 | G/T | — | benign |
| rs1395804635 | 7:50,742,236 | G/A | — | uncertain significance |
| rs1217448505 | 7:50,742,245 | G/C | — | uncertain significance |
| rs199989891 | 7:50,742,247 | C/G | — | uncertain significance |
| rs916597844 | 7:50,742,284 | T/C | — | uncertain significance |
| rs370148252 | 7:50,742,324 | G/A | — | likely benign |
| rs2190503 | 7:50,742,617 | A/T | — | — |
| rs56200772 | 7:50,743,947 | C/G | intron variant | — |
| rs757999 | 7:50,746,972 | G/A | regulatory region variant | — |
| rs10248619 | 7:50,751,090 | T/C | intron variant | — |
| rs148635648 | 7:50,751,250 | A/G | intron variant | — |
| rs2282930 | 7:50,754,679 | G/A | intron variant | — |
| rs2237490 | 7:50,757,541 | C/G | intron variant | — |
| rs2190502 | 7:50,763,624 | T/G | intron variant | — |
| rs73118830 | 7:50,764,948 | T/C | regulatory region variant | — |
| rs2529402 | 7:50,769,330 | G/C | intron variant | — |
| rs533088199 | 7:50,771,526 | T/C | — | benign |
| rs202022963 | 7:50,771,535 | C/T | — | uncertain significance |
| rs180853209 | 7:50,771,548 | C/T | — | uncertain significance |
| rs35647889 | 7:50,771,550 | G/A | — | benign |
| rs373419464 | 7:50,771,566 | C/T | — | uncertain significance |
| rs202059826 | 7:50,778,562 | G/A | — | likely benign |
| rs73122790 | 7:50,781,539 | T/A | intron variant | — |
| rs73124711 | 7:50,790,028 | C/T | intron variant | — |
| rs10265077 | 7:50,790,368 | G/T | intron variant | — |
| rs34061103 | 7:50,804,205 | G/T | — | — |
| rs17548938 | 7:50,807,425 | G/A | intron variant | — |
| rs6946194 | 7:50,839,837 | A/T | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.