GRM7
glutamate metabotropic receptor 7
Summary
L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
Known Variants221 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1255548681 | 3:6,903,101 | G/A | — | uncertain significance |
| rs751260701 | 3:6,903,117 | G/C | — | uncertain significance |
| rs1485463008 | 3:6,903,126 | C/T | — | likely benign |
| rs535666333 | 3:6,903,142 | G/A | — | benign |
| rs151191866 | 3:6,903,153 | C/T | — | likely benign |
| rs138762445 | 3:6,903,156 | G/C | — | benign |
| rs200656326 | 3:6,903,160 | G/A | — | uncertain significance |
| rs116111799 | 3:6,903,174 | C/A | — | benign |
| rs1442070924 | 3:6,903,175 | G/T | — | uncertain significance |
| rs114869468 | 3:6,903,189 | C/T | — | benign |
| rs1694754156 | 3:6,903,194 | C/T | — | uncertain significance |
| rs752485323 | 3:6,903,195 | G/T | — | likely benign |
| rs2470185607 | 3:6,903,205 | C/A | — | likely benign |
| rs142650646 | 3:6,903,219 | C/T | — | likely benign |
| rs369829293 | 3:6,903,234 | G/T | — | likely benign |
| rs767030116 | 3:6,903,269 | T/A | — | uncertain significance |
| rs1276377587 | 3:6,903,271 | C/T | — | uncertain significance |
| rs1211257058 | 3:6,903,286 | A/G | — | uncertain significance |
| rs3749380 | 3:6,903,297 | C/T | synonymous variant | benign |
| rs1477620935 | 3:6,903,298 | G/A | — | uncertain significance |
| rs536321812 | 3:6,903,303 | C/T | — | likely benign |
| rs2470186122 | 3:6,903,328 | G/T | — | uncertain significance |
| rs1282636247 | 3:6,903,360 | A/G | — | likely benign |
| rs1194802660 | 3:6,903,369 | C/A | — | uncertain significance |
| rs555598605 | 3:6,903,375 | G/T | — | likely benign |
| rs2470186324 | 3:6,903,378 | G/T | — | likely benign |
| rs1358525720 | 3:6,903,386 | G/T | — | uncertain significance |
| rs758351456 | 3:6,903,396 | C/T | — | likely benign |
| rs1311395503 | 3:6,903,399 | T/C | — | likely benign |
| rs781674511 | 3:6,903,402 | T/C | — | likely benign |
| rs2470186445 | 3:6,903,417 | C/A | — | pathogenic |
| rs748476058 | 3:6,903,424 | G/A | — | uncertain significance |
| rs1217880744 | 3:6,903,439 | T/A | — | uncertain significance |
| rs2124924479 | 3:6,903,443 | T/C | — | uncertain significance |
| rs1200043641 | 3:6,903,451 | C/T | — | uncertain significance |
| rs570680005 | 3:6,903,474 | C/T | — | likely benign |
| rs776294259 | 3:6,903,490 | G/A | — | uncertain significance |
| rs765027538 | 3:6,903,493 | G/C | — | uncertain significance |
| rs375507054 | 3:6,903,501 | G/A | — | likely benign |
| rs2124924619 | 3:6,903,507 | C/T | — | likely benign |
| rs1055345234 | 3:6,903,508 | G/C | — | uncertain significance |
| rs755132698 | 3:6,903,516 | G/C | — | likely benign |
| rs1114167298 | 3:6,903,536 | T/C | — | pathogenic |
| rs746479889 | 3:6,903,579 | C/A | — | likely benign |
| rs342034 | 3:6,903,601 | G/A | — | benign |
| rs144420141 | 3:6,989,605 | T/G | intron variant | — |
| rs480409 | 3:7,010,081 | C/T | intron variant | — |
| rs74971332 | 3:7,058,507 | C/G | intron variant | — |
| rs11928865 | 3:7,155,702 | T/G | — | — |
| rs139429824 | 3:7,188,171 | C/T | — | likely benign |
| rs35106713 | 3:7,188,180 | C/T | — | benign |
| rs144324520 | 3:7,188,188 | G/A | — | conflicting classifications of pathogenicity |
| rs201451182 | 3:7,188,216 | G/T | — | likely benign |
| rs761983302 | 3:7,188,223 | G/A | — | uncertain significance |
| rs2470281819 | 3:7,188,250 | G/A | — | uncertain significance |
| rs374449698 | 3:7,188,297 | G/A | — | likely benign |
| rs1235954876 | 3:7,188,335 | C/T | — | uncertain significance |
| rs1002646614 | 3:7,188,337 | C/A | — | uncertain significance |
| rs111261826 | 3:7,189,617 | A/T | — | — |
| rs150194225 | 3:7,340,375 | A/T | — | likely benign |
| rs144380165 | 3:7,340,393 | C/T | — | likely benign |
| rs368787807 | 3:7,340,394 | G/C | — | uncertain significance |
| rs974942605 | 3:7,340,411 | A/G | — | likely benign |
| rs1699899886 | 3:7,340,471 | C/A | — | uncertain significance |
| rs761307351 | 3:7,340,480 | C/T | — | likely benign |
| rs1284213715 | 3:7,340,481 | G/A | — | uncertain significance |
| rs945262806 | 3:7,340,487 | A/G | — | uncertain significance |
| rs752598578 | 3:7,340,516 | A/G | — | uncertain significance |
| rs868702610 | 3:7,348,179 | C/T | — | likely benign |
| rs961639252 | 3:7,348,189 | A/G | — | uncertain significance |
| rs753800759 | 3:7,348,201 | G/A | — | uncertain significance |
| rs750608558 | 3:7,348,212 | T/C | — | likely benign |
| rs1700200872 | 3:7,348,237 | G/A | — | uncertain significance |
| rs2125034611 | 3:7,348,257 | A/T | — | likely benign |
| rs747312914 | 3:7,348,262 | A/G | — | uncertain significance |
| rs2469971413 | 3:7,348,291 | A/G | — | uncertain significance |
| rs373414573 | 3:7,348,293 | C/T | — | likely benign |
| rs776521911 | 3:7,348,294 | G/A | — | uncertain significance |
| rs750463229 | 3:7,348,319 | C/T | — | uncertain significance |
| rs755371859 | 3:7,348,331 | C/T | — | uncertain significance |
| rs78137319 | 3:7,348,332 | G/A | — | benign |
| rs2469971571 | 3:7,348,339 | G/T | — | uncertain significance |
| rs12491620 | 3:7,394,333 | C/G | intron variant | — |
| rs13080594 | 3:7,403,646 | C/T | intron variant | — |
| rs138178952 | 3:7,444,873 | G/C | — | likely benign |
| rs150722276 | 3:7,456,729 | G/A | — | likely benign |
| rs2470184920 | 3:7,456,769 | G/A | — | uncertain significance |
| rs771129754 | 3:7,456,771 | C/T | — | likely benign |
| rs1248589034 | 3:7,456,787 | A/G | — | uncertain significance |
| rs139183375 | 3:7,456,807 | G/A | — | likely benign |
| rs200435397 | 3:7,456,831 | C/A | — | likely benign |
| rs2470185065 | 3:7,456,832 | A/G | — | uncertain significance |
| rs372923484 | 3:7,456,865 | G/A | — | likely benign |
| rs779867 | 3:7,484,471 | T/G | — | — |
| rs9865843 | 3:7,489,993 | A/G | intron variant | — |
| rs71308549 | 3:7,490,917 | C/A | — | — |
| rs778942212 | 3:7,494,288 | G/A | — | likely benign |
| rs34067965 | 3:7,494,298 | G/A | — | likely benign |
| rs1697820592 | 3:7,494,299 | G/A | — | pathogenic |
| rs1697821121 | 3:7,494,325 | T/C | — | likely benign |
Showing 100 of 221 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.