GTF2H4
general transcription factor IIH subunit 4
Summary
Enables RNA polymerase II general transcription initiation factor activity. Involved in transcription by RNA polymerase II. Located in nuclear speck. Part of core TFIIH complex portion of holo TFIIH complex and transcription factor TFIID complex. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants20 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs6920760 | 6:30,874,797 | C/T | coding sequence variant | — |
| rs1052693 | 6:30,876,152 | C/T | coding sequence variant | — |
| rs3218810 | 6:30,876,411 | T/C | regulatory region variant | — |
| rs2074508 | 6:30,876,438 | G/A | downstream gene variant | — |
| rs754833874 | 6:30,876,847 | G/A | — | uncertain significance |
| rs763585242 | 6:30,876,929 | C/G | — | uncertain significance |
| rs2538579991 | 6:30,877,216 | C/T | — | uncertain significance |
| rs774016030 | 6:30,877,740 | G/A | — | uncertain significance |
| rs1793725051 | 6:30,878,448 | G/C | — | uncertain significance |
| rs761145073 | 6:30,878,641 | C/G | — | uncertain significance |
| rs759691768 | 6:30,878,646 | T/C | — | uncertain significance |
| rs2538590092 | 6:30,879,480 | T/G | — | uncertain significance |
| rs1264308 | 6:30,879,987 | C/T | upstream gene variant | — |
| rs764390768 | 6:30,880,108 | C/T | — | uncertain significance |
| rs2230121 | 6:30,880,211 | C/T | — | benign |
| rs773820000 | 6:30,880,920 | G/A | — | uncertain significance |
| rs754532075 | 6:30,881,104 | A/C | — | uncertain significance |
| rs145276911 | 6:30,881,122 | C/G | — | uncertain significance |
| rs2538606731 | 6:30,881,636 | T/C | — | uncertain significance |
| rs761347915 | 6:30,881,741 | G/C | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.