H3C13
H3 clustered histone 13
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. [provided by RefSeq, Aug 2015]
Known Variants11 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2524834289 | 1:149,784,867 | C/T | — | uncertain significance |
| rs1571429866 | 1:149,784,908 | A/T | — | uncertain significance |
| rs782720234 | 1:149,784,975 | A/G | — | uncertain significance |
| rs1405770242 | 1:149,784,997 | C/G | — | uncertain significance |
| rs2524836359 | 1:149,785,028 | C/T | — | uncertain significance |
| rs7524039 | 1:149,785,039 | C/T | — | benign |
| rs587692197 | 1:149,785,063 | A/G | — | benign |
| rs1553754994 | 1:149,785,170 | T/C | — | uncertain significance |
| rs115659429 | 1:149,786,633 | G/A | — | — |
| rs145619620 | 1:149,786,651 | T/A | upstream gene variant | — |
| rs587746306 | 1:149,787,174 | C/T | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.