HCRTR2
hypocretin receptor 2
Summary
The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. [provided by RefSeq, Jan 2009]
Known Variants45 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs4715517 | 6:54,973,761 | C/A | regulatory region variant | — |
| rs1195245755 | 6:55,007,161 | A/T | — | — |
| rs73432965 | 6:55,008,880 | A/C | regulatory region variant | — |
| rs35833281 | 6:55,021,561 | G/C | intergenic variant | — |
| rs79986767 | 6:55,033,198 | T/C | intergenic variant | — |
| rs41271310 | 6:55,039,413 | C/T | — | likely benign |
| rs143272352 | 6:55,039,415 | C/T | — | likely benign |
| rs200969438 | 6:55,039,426 | A/G | — | uncertain significance |
| rs202246026 | 6:55,039,543 | A/G | — | uncertain significance |
| rs1479472421 | 6:55,039,548 | T/C | — | uncertain significance |
| rs141403220 | 6:55,039,564 | G/T | — | uncertain significance |
| rs1581808017 | 6:55,039,590 | C/T | — | uncertain significance |
| rs150493791 | 6:55,039,598 | G/A | — | likely benign |
| rs9370399 | 6:55,045,025 | A/G | — | — |
| rs566092291 | 6:55,063,408 | T/G | — | — |
| rs3122169 | 6:55,113,411 | C/A | intron variant | — |
| rs568265545 | 6:55,113,508 | G/T | — | uncertain significance |
| rs75705481 | 6:55,113,527 | T/C | — | uncertain significance |
| rs113561951 | 6:55,119,975 | C/T | — | benign |
| rs372046428 | 6:55,120,040 | G/A | — | uncertain significance |
| rs200667471 | 6:55,120,078 | A/G | — | uncertain significance |
| rs41381449 | 6:55,120,108 | T/A | — | likely benign |
| rs201852099 | 6:55,120,133 | C/G | — | uncertain significance |
| rs369531858 | 6:55,120,168 | C/T | — | uncertain significance |
| rs1257693637 | 6:55,128,534 | T/G | — | uncertain significance |
| rs1341054333 | 6:55,128,594 | A/G | — | uncertain significance |
| rs199660644 | 6:55,128,601 | G/T | — | uncertain significance |
| rs2653344 | 6:55,133,586 | T/C | intron variant | — |
| rs2134294 | 6:55,134,247 | T/C | intron variant | — |
| rs188055163 | 6:55,136,442 | A/C | intron variant | — |
| rs3800539 | 6:55,141,019 | G/C | — | — |
| rs368394177 | 6:55,142,193 | T/A | — | uncertain significance |
| rs756748911 | 6:55,142,242 | G/A | — | uncertain significance |
| rs12111299 | 6:55,142,261 | G/A | — | benign |
| rs2653349 | 6:55,142,337 | A/G | missense variant | benign |
| rs201429627 | 6:55,142,379 | A/G | — | uncertain significance |
| rs375477231 | 6:55,147,073 | G/C | — | uncertain significance |
| rs2481207422 | 6:55,147,090 | G/C | — | uncertain significance |
| rs146725330 | 6:55,147,099 | C/T | — | benign |
| rs200490413 | 6:55,147,137 | T/G | — | uncertain significance |
| rs2481207638 | 6:55,147,145 | C/G | — | uncertain significance |
| rs200022759 | 6:55,147,151 | A/G | — | uncertain significance |
| rs141299250 | 6:55,147,209 | C/A | — | conflicting classifications of pathogenicity |
| rs1445140705 | 6:55,147,224 | A/G | — | uncertain significance |
| rs9367630 | 6:55,148,103 | G/T | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.