rs2653349

This is a variant in the HCRTR2 gene that changes a isoleucine to an valine.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

daytime rest measurement

Dashti HS et al. “Genetic determinants of daytime napping and effects on cardiometabolic health.” Nature Communications 12(1):900 (2021)
Allele A
OR 0.02
p 6.0e-52
N 452,633
Large GWAS
European

chronotype measurement

Jones SE et al. “Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms.” Nature Communications 10(1):343 (2019)
Allele A
OR 1.07
p 3.0e-48
N 449,734
Large GWAS
European
Jansen PR et al. “Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways.” Nature Genetics 51(3):394-403 (2019)
Allele A
OR 0.03
p 1.0e-32
N 434,835
Large GWAS
European
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ClinVar annotation

Benign
1 submitter

HCRTR2-related disorder

View on ClinVar →

About HCRTR2

The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. [provided by RefSeq, Jan 2009]

View all HCRTR2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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