IL10

interleukin 10

Summary

The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. [provided by RefSeq, May 2020]

Known Variants115 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs3024498	1:206,941,529	T/C	regulatory region variant	—
rs3024496	1:206,941,864	A/G	3 prime UTR variant	benign
rs771277922	1:206,941,984	G/C	—	uncertain significance
rs376415487	1:206,941,988	C/T	—	uncertain significance
rs142726516	1:206,941,989	G/A	—	uncertain significance
rs762496248	1:206,941,997	A/G	—	uncertain significance
rs768418064	1:206,942,004	T/C	—	uncertain significance
rs1572537757	1:206,942,005	G/A	—	likely benign
rs142093260	1:206,942,008	G/A	—	likely benign
rs568879359	1:206,942,011	T/G	—	uncertain significance
rs1310781150	1:206,942,015	A/T	—	uncertain significance
rs2102436707	1:206,942,016	T/C	—	uncertain significance
rs1674735790	1:206,942,047	G/T	—	likely benign
rs2526381212	1:206,942,081	G/A	—	likely benign
rs3024495	1:206,942,413	C/A	—	—
rs2526386275	1:206,943,154	C/T	—	likely benign
rs2526386281	1:206,943,157	C/T	—	likely benign
rs1433173306	1:206,943,166	A/G	—	likely benign
rs749664677	1:206,943,168	G/A	—	uncertain significance
rs1490806720	1:206,943,175	T/C	—	uncertain significance
rs774072665	1:206,943,184	G/A	—	uncertain significance
rs1674768626	1:206,943,194	C/G	—	uncertain significance
rs771681458	1:206,943,204	G/C	—	likely benign
rs1229974502	1:206,943,225	G/A	—	likely benign
rs1319282028	1:206,943,232	A/T	—	uncertain significance
rs760677075	1:206,943,235	C/A	—	uncertain significance
rs776223407	1:206,943,255	G/A	—	likely benign
rs1467623325	1:206,943,256	A/G	—	likely benign
rs759391400	1:206,943,258	A/C	—	likely benign
rs3024509	1:206,943,297	A/G	regulatory region variant	—
rs3024494	1:206,943,351	T/C	—	benign
rs1878672	1:206,943,713	G/C	intron variant	—
rs3024493	1:206,943,968	C/A	regulatory region variant	benign
rs3024492	1:206,944,112	T/A	regulatory region variant	—
rs1554286	1:206,944,233	A/G	regulatory region variant	benign
rs371748044	1:206,944,236	C/G	—	likely benign
rs1674809964	1:206,944,237	T/G	—	likely benign
rs1234119769	1:206,944,246	A/G	—	uncertain significance
rs755403362	1:206,944,255	G/T	—	likely benign
rs374619208	1:206,944,256	C/T	—	uncertain significance
rs991441780	1:206,944,258	C/T	—	likely benign
rs201365412	1:206,944,259	C/T	—	uncertain significance
rs746523858	1:206,944,260	G/A	—	uncertain significance
rs371608920	1:206,944,265	C/T	—	uncertain significance
rs1162694380	1:206,944,269	G/A	—	likely benign
rs5743626	1:206,944,285	G/A	—	likely benign
rs150423829	1:206,944,287	T/A	—	uncertain significance
rs767727378	1:206,944,294	C/G	—	likely benign
rs2102439153	1:206,944,296	G/A	—	likely benign
rs1674812448	1:206,944,298	G/A	—	uncertain significance
rs750441744	1:206,944,303	C/T	—	likely benign
rs1307541646	1:206,944,307	T/C	—	uncertain significance
rs560908141	1:206,944,309	C/T	—	likely benign
rs755490123	1:206,944,310	G/A	—	uncertain significance
rs372883095	1:206,944,316	A/C	—	uncertain significance
rs987614203	1:206,944,321	T/C	—	likely benign
rs777582308	1:206,944,329	G/T	—	uncertain significance
rs1220388430	1:206,944,333	C/T	—	likely benign
rs1674814817	1:206,944,354	C/T	—	likely benign
rs780612967	1:206,944,356	C/T	—	uncertain significance
rs1674815134	1:206,944,357	C/T	—	likely benign
rs1674815548	1:206,944,369	G/A	—	likely benign
rs2526391945	1:206,944,373	A/T	—	uncertain significance
rs769682299	1:206,944,375	C/T	—	likely benign
rs775288303	1:206,944,378	A/C	—	likely benign
rs2102439318	1:206,944,389	G/T	—	uncertain significance
rs139352858	1:206,944,402	A/G	—	likely benign
rs1518111	1:206,944,645	T/C	regulatory region variant	benign
rs1372528108	1:206,944,681	C/T	—	likely benign
rs376490444	1:206,944,683	C/T	—	likely benign
rs1674832645	1:206,944,684	C/T	—	likely benign
rs1342823726	1:206,944,686	C/T	—	likely benign
rs749041176	1:206,944,695	T/C	—	uncertain significance
rs545228684	1:206,944,711	T/C	—	uncertain significance
rs1674835162	1:206,944,713	C/A	—	likely benign
rs1558603013	1:206,944,717	A/T	—	uncertain significance
rs2102439750	1:206,944,725	C/T	—	likely benign
rs2526394480	1:206,944,767	G/A	—	likely benign
rs191140520	1:206,944,775	A/G	—	benign
rs763601604	1:206,944,779	G/A	—	likely benign
rs1518110	1:206,944,861	A/C	—	benign
rs3021094	1:206,944,952	T/G	intron variant	—
rs3024491	1:206,945,046	C/T	—	—
rs3790622	1:206,945,163	G/A	intron variant	—
rs3024490	1:206,945,311	A/T	—	—
rs2222202	1:206,945,381	G/A	intron variant	—
rs749899175	1:206,945,596	C/T	—	likely benign
rs373813224	1:206,945,601	A/G	—	likely benign
rs749203652	1:206,945,602	G/A	—	likely benign
rs530302888	1:206,945,608	A/G	—	benign
rs769965755	1:206,945,644	T/C	—	uncertain significance
rs2526399585	1:206,945,646	T/G	—	likely benign
rs550164520	1:206,945,647	C/T	—	uncertain significance
rs750010814	1:206,945,660	G/A	—	uncertain significance
rs755837237	1:206,945,663	T/C	—	uncertain significance
rs932830694	1:206,945,669	G/C	—	uncertain significance
rs2102441015	1:206,945,681	G/T	—	uncertain significance
rs376787667	1:206,945,687	G/T	—	uncertain significance
rs752491913	1:206,945,689	G/A	—	uncertain significance
rs945097885	1:206,945,697	G/A	—	likely benign

Showing 100 of 115 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.