ILF3
interleukin enhancer binding factor 3
Summary
This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2014]
Known Variants47 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs7250071 | 19:10,765,819 | C/T | regulatory region variant | — |
| rs2360944 | 19:10,769,974 | T/A | — | — |
| rs12459481 | 19:10,770,767 | C/T | — | — |
| rs10407692 | 19:10,770,783 | A/G | intron variant | — |
| rs186673316 | 19:10,771,664 | C/T | intron variant | — |
| rs147622113 | 19:10,771,941 | C/T | intron variant | — |
| rs2043304 | 19:10,772,112 | T/A | — | — |
| rs4435370 | 19:10,774,623 | G/C | — | — |
| rs2067857082 | 19:10,781,680 | C/T | — | uncertain significance |
| rs2512660646 | 19:10,781,690 | T/C | — | uncertain significance |
| rs140639398 | 19:10,781,718 | A/C | — | likely benign |
| rs1449982046 | 19:10,781,870 | A/G | — | uncertain significance |
| rs769110376 | 19:10,782,045 | C/T | — | uncertain significance |
| rs755638784 | 19:10,782,133 | G/T | — | uncertain significance |
| rs763112552 | 19:10,782,200 | A/G | — | uncertain significance |
| rs577628286 | 19:10,785,067 | C/T | — | — |
| rs1982075 | 19:10,787,744 | C/G | intron variant | — |
| rs1459465854 | 19:10,787,845 | A/G | — | uncertain significance |
| rs2068122354 | 19:10,787,870 | A/C | — | uncertain significance |
| rs775323811 | 19:10,789,851 | G/C | — | uncertain significance |
| rs2569512 | 19:10,790,162 | T/C | intron variant | — |
| rs755415541 | 19:10,791,749 | C/T | — | uncertain significance |
| rs2068263275 | 19:10,791,880 | G/A | — | likely benign |
| rs1568231962 | 19:10,791,957 | G/A | — | uncertain significance |
| rs755193398 | 19:10,792,677 | G/T | — | uncertain significance |
| rs777089402 | 19:10,792,710 | C/T | — | uncertain significance |
| rs759654339 | 19:10,792,863 | G/A | — | uncertain significance |
| rs779369130 | 19:10,793,234 | C/G | — | uncertain significance |
| rs746308239 | 19:10,793,262 | G/A | — | uncertain significance |
| rs148148089 | 19:10,793,294 | G/A | — | uncertain significance |
| rs780654204 | 19:10,793,313 | C/T | — | uncertain significance |
| rs138735290 | 19:10,793,352 | C/T | — | uncertain significance |
| rs755231327 | 19:10,794,150 | G/T | — | uncertain significance |
| rs1007870178 | 19:10,794,339 | G/A | — | uncertain significance |
| rs139961882 | 19:10,794,413 | G/A | — | benign |
| rs768178191 | 19:10,794,619 | G/A | — | uncertain significance |
| rs2229383 | 19:10,794,630 | G/T | synonymous variant | — |
| rs746150437 | 19:10,798,096 | G/A | — | uncertain significance |
| rs758103015 | 19:10,798,153 | G/A | — | uncertain significance |
| rs2068504602 | 19:10,798,274 | A/T | — | uncertain significance |
| rs2512870171 | 19:10,798,348 | G/A | — | uncertain significance |
| rs2569507 | 19:10,798,904 | G/A | regulatory region variant | — |
| rs771545655 | 19:10,799,226 | A/G | — | uncertain significance |
| rs200944645 | 19:10,799,252 | G/A | — | likely benign |
| rs2068536975 | 19:10,799,330 | G/A | — | uncertain significance |
| rs12463078 | 19:10,799,622 | G/C | — | — |
| rs2512884604 | 19:10,799,926 | C/G | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.