IRF7

interferon regulatory factor 7

Summary

This gene encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. It has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. The encoded protein plays an important role in the innate immune response against DNA and RNA viruses. [provided by RefSeq, Jul 2021]

Known Variants512 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs1444359880	11:612,649	G/A	—	uncertain significance
rs1856495354	11:612,651	G/A	—	likely benign
rs1298847378	11:612,667	A/G	—	uncertain significance
rs2133123774	11:612,678	C/G	—	uncertain significance
rs750066562	11:612,680	C/G	—	uncertain significance
rs755671976	11:612,681	G/T	—	likely benign
rs1802427	11:612,686	C/T	—	uncertain significance
rs768723507	11:612,687	G/A	—	likely benign
rs2493880348	11:612,689	C/T	—	uncertain significance
rs778977149	11:612,696	G/T	—	uncertain significance
rs772836644	11:612,704	C/T	—	conflicting classifications of pathogenicity
rs144437378	11:612,705	G/T	—	uncertain significance
rs2493881402	11:612,713	G/A	—	likely benign
rs1589916026	11:612,723	G/A	—	likely benign
rs2493882095	11:612,734	T/C	—	uncertain significance
rs1157609757	11:612,738	C/T	—	uncertain significance
rs2493882274	11:612,742	G/C	—	uncertain significance
rs1159331161	11:612,747	C/T	—	likely benign
rs752030532	11:612,751	C/T	—	uncertain significance
rs762132411	11:612,757	C/A	—	uncertain significance
rs750711497	11:612,762	C/G	—	likely benign
rs779790369	11:612,763	G/A	—	uncertain significance
rs1589916130	11:612,764	T/A	—	uncertain significance
rs1350285168	11:612,766	C/T	—	uncertain significance
rs1589916143	11:612,767	C/T	—	uncertain significance
rs375003348	11:612,770	C/T	—	uncertain significance
rs147838432	11:612,774	G/A	—	likely benign
rs1180903297	11:612,775	T/G	—	uncertain significance
rs748141441	11:612,777	C/A	—	likely benign
rs758231153	11:612,781	C/T	—	uncertain significance
rs758818635	11:612,789	C/T	—	uncertain significance
rs746725871	11:612,791	A/G	—	uncertain significance
rs370946255	11:612,793	G/A	—	uncertain significance
rs1008659575	11:612,797	C/T	—	uncertain significance
rs2493883551	11:612,799	A/C	—	uncertain significance
rs1856508713	11:612,805	C/T	—	uncertain significance
rs2493883681	11:612,807	G/A	—	likely benign
rs768699608	11:612,815	C/T	—	likely benign
rs774363859	11:612,816	G/A	—	likely benign
rs200469975	11:612,818	G/A	—	benign
rs10902178	11:612,843	T/G	—	benign
rs11246213	11:612,967	A/G	—	benign
rs1279149786	11:612,980	C/A	—	likely benign
rs1856527141	11:612,983	G/A	—	likely benign
rs1856527650	11:612,987	C/T	—	likely benign
rs200063173	11:612,999	C/G	—	uncertain significance
rs141451948	11:613,005	C/T	—	likely benign
rs1856529585	11:613,009	A/T	—	uncertain significance
rs150387655	11:613,017	C/T	—	likely benign
rs1302421672	11:613,035	A/C	—	likely benign
rs773112663	11:613,042	A/G	—	uncertain significance
rs1419573326	11:613,043	G/A	—	likely benign
rs945551950	11:613,047	C/T	—	likely benign
rs780994139	11:613,052	C/T	—	uncertain significance
rs762797158	11:613,053	G/A	—	likely benign
rs1856533236	11:613,066	A/T	—	uncertain significance
rs1331087922	11:613,069	G/C	—	uncertain significance
rs1030581700	11:613,070	T/C	—	uncertain significance
rs748323177	11:613,071	A/G	—	likely benign
rs772011524	11:613,075	C/T	—	uncertain significance
rs201165872	11:613,076	G/A	—	uncertain significance
rs149039709	11:613,087	C/G	—	uncertain significance
rs1388334813	11:613,090	C/T	—	uncertain significance
rs375323253	11:613,094	G/A	stop gained	pathogenic
rs377416331	11:613,096	C/T	—	uncertain significance
rs143070036	11:613,097	G/A	—	likely benign
rs1209884854	11:613,100	C/T	—	uncertain significance
rs142523418	11:613,102	C/T	—	uncertain significance
rs944667389	11:613,103	G/A	—	uncertain significance
rs767381892	11:613,110	C/T	—	likely benign
rs368955367	11:613,112	C/T	—	uncertain significance
rs755896373	11:613,114	A/G	—	uncertain significance
rs1289123378	11:613,122	A/G	—	likely benign
rs1337814410	11:613,123	G/C	—	likely benign
rs752888043	11:613,124	A/T	—	likely benign
rs777724108	11:613,128	G/T	—	likely benign
rs771624398	11:613,131	C/T	—	likely benign
rs781763496	11:613,136	C/T	—	likely benign
rs1289625680	11:613,137	T/G	—	uncertain significance
rs1051390	11:613,165	G/C	—	benign
rs1425489891	11:613,186	C/T	—	likely benign
rs12422022	11:613,192	A/G	—	benign
rs1369741739	11:613,195	G/A	—	likely benign
rs376213301	11:613,196	C/A	—	likely benign
rs1131665	11:613,208	T/C	missense variant	benign
rs786205223	11:613,215	A/C	missense variant	uncertain significance
rs764365065	11:613,219	T/A	—	uncertain significance
rs2493894152	11:613,226	T/G	—	uncertain significance
rs757383689	11:613,227	C/T	—	uncertain significance
rs746399119	11:613,231	G/A	—	likely benign
rs1484166244	11:613,233	T/C	—	uncertain significance
rs1856548155	11:613,236	G/A	—	uncertain significance
rs942117850	11:613,237	G/T	—	likely benign
rs1039452743	11:613,238	G/A	—	uncertain significance
rs2493894620	11:613,245	A/G	—	uncertain significance
rs1170269409	11:613,246	G/C	—	uncertain significance
rs900460497	11:613,249	C/A	—	likely benign
rs771545271	11:613,259	A/C	—	uncertain significance
rs1300271615	11:613,261	G/A	—	likely benign
rs1257744960	11:613,263	A/T	—	uncertain significance

Showing 100 of 512 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.