IRF8

interferon regulatory factor 8

Summary

Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. [provided by RefSeq, Jul 2008]

Known Variants310 total

rsidPosition (GRCh37)AllelesClassClinVar
rs151997816:85,935,211A/Tintron variant—
rs50557716:85,936,389T/A—benign
rs37456356516:85,936,627T/C—likely benign
rs88603959616:85,936,630C/Gmissense variantuncertain significance
rs106479626216:85,936,631C/T—uncertain significance
rs20146446716:85,936,640G/A—uncertain significance
rs129343966716:85,936,643C/T—uncertain significance
rs75957954316:85,936,646C/T—uncertain significance
rs138887633816:85,936,656A/T—uncertain significance
rs254499641616:85,936,657G/A—likely benign
rs76495867916:85,936,666C/G—uncertain significance
rs134736612116:85,936,667G/A—uncertain significance
rs139125161816:85,936,677A/G—uncertain significance
rs159724901516:85,936,679A/G—uncertain significance
rs37707073916:85,936,680G/A—uncertain significance
rs37008618116:85,936,689A/G—uncertain significance
rs190487810116:85,936,691C/G—uncertain significance
rs98859193916:85,936,696A/G—likely benign
rs74970072816:85,936,702T/A—likely benign
rs123405932416:85,936,708G/A—likely benign
rs77090594316:85,936,719A/G—uncertain significance
rs190487958916:85,936,722G/A—uncertain significance
rs20077585416:85,936,723C/G—uncertain significance
rs14092113116:85,936,725T/C—uncertain significance
rs15019378116:85,936,747C/T—likely benign
rs254499652816:85,936,751G/A—uncertain significance
rs190488237316:85,936,795G/A—uncertain significance
rs190488247316:85,936,799A/G—uncertain significance
rs254499658316:85,936,813C/T—likely benign
rs992666416:85,938,755A/Gintron variant—
rs11760011616:85,940,413A/Gintron variant—
rs1051461016:85,942,175G/A——
rs76023363016:85,942,582G/A—likely benign
rs75324534616:85,942,588T/C—likely benign
rs125553515616:85,942,593C/T—uncertain significance
rs159725189016:85,942,605G/A—uncertain significance
rs77180506716:85,942,639C/T—uncertain significance
rs215210069316:85,942,648C/T—uncertain significance
rs39751471116:85,942,659A/Gmissense variantpathogenic
rs190507563916:85,942,660C/G—uncertain significance
rs254500098616:85,942,671T/C—uncertain significance
rs75204366816:85,942,682T/C—likely benign
rs14504896616:85,942,708C/T—likely benign
rs11137952816:85,942,709G/A—likely benign
rs3471237416:85,942,710G/A—uncertain significance
rs254500103616:85,942,714G/A—uncertain significance
rs1154556416:85,942,721A/G—benign
rs54177953416:85,942,733C/T—likely benign
rs254500106716:85,942,736G/A—likely benign
rs39751471016:85,942,743A/Gmissense variantpathogenic
rs37194284216:85,942,753G/A—uncertain significance
rs254500110116:85,942,764G/C—uncertain significance
rs20004026316:85,942,783A/T—uncertain significance
rs190507871616:85,942,786A/T—likely benign
rs135439973916:85,942,788C/T—likely benign
rs125319059516:85,942,795G/C—likely benign
rs20061782216:85,942,797G/A—likely benign
rs39152516:85,944,439A/C——
rs229298016:85,945,076T/C—benign
rs190514260716:85,945,160G/A—likely benign
rs97835048816:85,945,169T/A—likely benign
rs76530026816:85,945,170C/T—likely benign
rs75273885116:85,945,172G/A—likely benign
rs14594353716:85,945,179A/T—uncertain significance
rs77783559116:85,945,186C/T—likely benign
rs13885437416:85,945,187G/A—likely benign
rs190514363516:85,945,188T/A—uncertain significance
rs75711665416:85,945,193A/G—conflicting classifications of pathogenicity
rs143538225816:85,945,194C/G—uncertain significance
rs215210151016:85,945,197C/T—uncertain significance
rs78085617016:85,945,198T/A—likely benign
rs1693994116:85,945,204C/T—benign
rs76935629316:85,945,205G/A—uncertain significance
rs190514504616:85,945,215T/C—uncertain significance
rs155550929316:85,945,223A/G—uncertain significance
rs215210152916:85,945,230G/A—uncertain significance
rs805206416:85,945,231C/T—uncertain significance
rs13803289116:85,945,232G/A—likely benign
rs36903342316:85,945,234T/G—likely benign
rs75299909516:85,945,235C/T—uncertain significance
rs37286361216:85,945,236G/A—uncertain significance
rs75727610316:85,945,246C/T—likely benign
rs1693994516:85,945,249T/C—benign
rs75597843416:85,945,250G/A—uncertain significance
rs139151160116:85,945,252G/A—likely benign
rs92599416:85,946,017C/Aregulatory region variant—
rs42497116:85,946,450T/A——
rs75463636916:85,946,725C/G—likely benign
rs74562906416:85,946,734C/T—uncertain significance
rs15052133116:85,946,748C/T—likely benign
rs77601303516:85,946,750A/T—uncertain significance
rs215210195116:85,946,766C/T—likely benign
rs74947480116:85,946,772G/A—likely benign
rs136345749916:85,946,774G/C—uncertain significance
rs121235691916:85,946,775C/A—uncertain significance
rs53234121616:85,946,784G/A—likely benign
rs14943906116:85,946,786C/T—uncertain significance
rs77301809216:85,946,787G/A—likely benign
rs76945646216:85,946,797C/G—uncertain significance
rs75458119316:85,946,799G/C—likely benign

Showing 100 of 310 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.