KSR1

kinase suppressor of ras 1

Summary

Enables 14-3-3 protein binding activity and ATP binding activity. Involved in positive regulation of MAPK cascade. Located in cytosol; endoplasmic reticulum; and membrane. Part of protein-containing complex. Implicated in breast adenocarcinoma. Biomarker of breast cancer. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants46 total

rsidPosition (GRCh37)AllelesClassClinVar
rs294541217:25,843,643G/Aintron variant
rs110552717:25,848,196C/Tintron variant
rs294853617:25,864,514T/G
rs55490217517:25,903,367T/G
rs99636621617:25,904,593T/Cuncertain significance
rs254473261617:25,904,594G/Auncertain significance
rs37219455217:25,904,617G/Auncertain significance
rs19951910717:25,909,701A/Cuncertain significance
rs20057132417:25,909,714C/Tuncertain significance
rs52918538717:25,909,785A/Cuncertain significance
rs94776729217:25,909,827C/Auncertain significance
rs74798197317:25,909,947C/Tuncertain significance
rs19993153317:25,909,984G/Auncertain significance
rs76237506517:25,909,987G/Auncertain significance
rs77746651817:25,910,011G/Auncertain significance
rs37547278017:25,910,023C/Auncertain significance
rs75221626717:25,910,032G/Auncertain significance
rs254475818117:25,910,109A/Cuncertain significance
rs14929839717:25,910,740A/Gintron variant
rs37227544617:25,915,542G/Auncertain significance
rs76237314917:25,919,611G/Auncertain significance
rs20069255517:25,924,319T/Cuncertain significance
rs75520531217:25,924,373C/Tuncertain significance
rs105432438117:25,930,887C/Tuncertain significance
rs207365667617:25,930,889C/Guncertain significance
rs207365677117:25,930,892C/Tuncertain significance
rs76598818717:25,931,710G/Auncertain significance
rs75475398117:25,931,720C/Tuncertain significance
rs37062573417:25,932,517G/Auncertain significance
rs55639882317:25,932,545G/Auncertain significance
rs76642282717:25,932,598G/Auncertain significance
rs74539546917:25,932,637G/Auncertain significance
rs54546473817:25,932,712G/Auncertain significance
rs76471065917:25,934,962C/Tuncertain significance
rs20049136317:25,936,279G/Auncertain significance
rs19273176917:25,936,318G/Auncertain significance
rs37238779717:25,937,102C/Guncertain significance
rs140572073317:25,937,112C/Guncertain significance
rs77165638417:25,937,164C/Auncertain significance
rs254488772717:25,938,617C/Tuncertain significance
rs130015248417:25,938,618G/Auncertain significance
rs56009986617:25,944,348G/Alikely benign
rs20157326317:25,944,406A/Guncertain significance
rs5584298817:25,944,477A/Gupstream gene variant
rs14063132017:25,946,605G/Aupstream gene variant
rs54727375217:25,946,740A/T

Gene information from NCBI Gene. Variant classifications from ClinVar.