KSR1
kinase suppressor of ras 1
Summary
Enables 14-3-3 protein binding activity and ATP binding activity. Involved in positive regulation of MAPK cascade. Located in cytosol; endoplasmic reticulum; and membrane. Part of protein-containing complex. Implicated in breast adenocarcinoma. Biomarker of breast cancer. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants46 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2945412 | 17:25,843,643 | G/A | intron variant | — |
| rs1105527 | 17:25,848,196 | C/T | intron variant | — |
| rs2948536 | 17:25,864,514 | T/G | — | — |
| rs554902175 | 17:25,903,367 | T/G | — | — |
| rs996366216 | 17:25,904,593 | T/C | — | uncertain significance |
| rs2544732616 | 17:25,904,594 | G/A | — | uncertain significance |
| rs372194552 | 17:25,904,617 | G/A | — | uncertain significance |
| rs199519107 | 17:25,909,701 | A/C | — | uncertain significance |
| rs200571324 | 17:25,909,714 | C/T | — | uncertain significance |
| rs529185387 | 17:25,909,785 | A/C | — | uncertain significance |
| rs947767292 | 17:25,909,827 | C/A | — | uncertain significance |
| rs747981973 | 17:25,909,947 | C/T | — | uncertain significance |
| rs199931533 | 17:25,909,984 | G/A | — | uncertain significance |
| rs762375065 | 17:25,909,987 | G/A | — | uncertain significance |
| rs777466518 | 17:25,910,011 | G/A | — | uncertain significance |
| rs375472780 | 17:25,910,023 | C/A | — | uncertain significance |
| rs752216267 | 17:25,910,032 | G/A | — | uncertain significance |
| rs2544758181 | 17:25,910,109 | A/C | — | uncertain significance |
| rs149298397 | 17:25,910,740 | A/G | intron variant | — |
| rs372275446 | 17:25,915,542 | G/A | — | uncertain significance |
| rs762373149 | 17:25,919,611 | G/A | — | uncertain significance |
| rs200692555 | 17:25,924,319 | T/C | — | uncertain significance |
| rs755205312 | 17:25,924,373 | C/T | — | uncertain significance |
| rs1054324381 | 17:25,930,887 | C/T | — | uncertain significance |
| rs2073656676 | 17:25,930,889 | C/G | — | uncertain significance |
| rs2073656771 | 17:25,930,892 | C/T | — | uncertain significance |
| rs765988187 | 17:25,931,710 | G/A | — | uncertain significance |
| rs754753981 | 17:25,931,720 | C/T | — | uncertain significance |
| rs370625734 | 17:25,932,517 | G/A | — | uncertain significance |
| rs556398823 | 17:25,932,545 | G/A | — | uncertain significance |
| rs766422827 | 17:25,932,598 | G/A | — | uncertain significance |
| rs745395469 | 17:25,932,637 | G/A | — | uncertain significance |
| rs545464738 | 17:25,932,712 | G/A | — | uncertain significance |
| rs764710659 | 17:25,934,962 | C/T | — | uncertain significance |
| rs200491363 | 17:25,936,279 | G/A | — | uncertain significance |
| rs192731769 | 17:25,936,318 | G/A | — | uncertain significance |
| rs372387797 | 17:25,937,102 | C/G | — | uncertain significance |
| rs1405720733 | 17:25,937,112 | C/G | — | uncertain significance |
| rs771656384 | 17:25,937,164 | C/A | — | uncertain significance |
| rs2544887727 | 17:25,938,617 | C/T | — | uncertain significance |
| rs1300152484 | 17:25,938,618 | G/A | — | uncertain significance |
| rs560099866 | 17:25,944,348 | G/A | — | likely benign |
| rs201573263 | 17:25,944,406 | A/G | — | uncertain significance |
| rs55842988 | 17:25,944,477 | A/G | upstream gene variant | — |
| rs140631320 | 17:25,946,605 | G/A | upstream gene variant | — |
| rs547273752 | 17:25,946,740 | A/T | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.